Structure of PDB 1stx Chain A Binding Site BS08
Receptor Information
>1stx Chain A (length=244) Species:
562
(Escherichia coli) [
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SLRSDLINALYDENQKYDVCGIISAEGKIYPLGSDTAVLSTIFELFSRPI
INKIAEKHGYIVEEPKQQNHYPDFTLYKPSEPNKKIAIDIKTTYTNKENE
KIKFTLGGYTSFIRNNTKNIVYPFDQYIAHWIIGYVYTRVATRKSSLKTY
NINELNEIPKPYKGVKVFLQDKWVIAGDLAGSGNTTNIGSIHAHYKDFVE
GKGIFDSEDEFLDYWRNYERTSQLRNDKYNNISEYRNWIYRGRK
Ligand information
Ligand ID
MN
InChI
InChI=1S/Mn/q+2
InChIKey
WAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341
[Mn++]
Formula
Mn
Name
MANGANESE (II) ION
ChEMBL
DrugBank
DB06757
ZINC
PDB chain
1stx Chain A Residue 1007 [
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Receptor-Ligand Complex Structure
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PDB
1stx
DNA cleavage by EcoRV endonuclease: two metal ions in three metal ion binding sites
Resolution
2.1 Å
Binding residue
(original residue number in PDB)
K102 I103 H193
Binding residue
(residue number reindexed from 1)
K101 I102 H192
Annotation score
4
Enzymatic activity
Enzyme Commision number
3.1.21.4
: type II site-specific deoxyribonuclease.
Gene Ontology
Molecular Function
GO:0003677
DNA binding
GO:0004519
endonuclease activity
GO:0009036
type II site-specific deoxyribonuclease activity
GO:0046872
metal ion binding
Biological Process
GO:0009307
DNA restriction-modification system
View graph for
Molecular Function
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Biological Process
External links
PDB
RCSB:1stx
,
PDBe:1stx
,
PDBj:1stx
PDBsum
1stx
PubMed
15170321
UniProt
P04390
|T2E5_ECOLX Type II restriction enzyme EcoRV (Gene Name=ecoRVR)
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