Structure of PDB 1srp Chain A Binding Site BS08

Receptor Information

>1srp Chain A (length=468) Species: 617 (Serratia sp. E-15)

TGYDAVDDLLHYHERGNGIQINGKDSFSNEQAGLFITRENQTWNGYKVFG
QPVKLTFSFPDYKFSSTNVAGDTGLSKFSAEQQQQAKLSLQSWADVANIT
FTEVAAGQKANITFGNYSQDRPGHYDYGTQAYAFLPNTIWQGQDLGGQTW
YNVNQSNVKHPATEDYGRQTFTHEIGHALGLSHPGDYNAGEGNPTYRDVT
YAEDTRQFSLMSYWSETNTGGDNGGHYAAAPLLDDIAAIQHLYGANLSTR
TGDTVYGFNSNTGRDFLSTTSNSQKVIFAAWDAGGNDTFDFSGYTANQRI
NLNEKSFSDVGGLKGNVSIAAGVTIENAIGGSGNDVIVGNAANNVLKGGA
GNDVLFGGGGADELWGGAGKDIFVFSAASDSAPGASDWIRDFQKGIDKID
LSFFNKEAQSSDFIHFVDHFSGAAGEALLSYNASNNVTDLSVNIGGHQAP
DFLVKIVGQVDVATDFIV

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 1srp Chain A Residue 920

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1srp Crystal structure of Serratia protease, a zinc-dependent proteinase from Serratia sp. E-15, containing a beta-sheet coil motif at 2.0 A resolution.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): H176 H180 H186
• Binding residue (residue number reindexed from 1): H173 H177 H183
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.24.40: serralysin.

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0005509 calcium ion binding
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0031012 extracellular matrix

External links

• PDB: RCSB:1srp, PDBe:1srp, PDBj:1srp
• PDBsum: 1srp
• PubMed: 8797082
• UniProt: P07268|PRZN_SERME Serralysin