Structure of PDB 1a7s Chain A Binding Site BS08
Receptor Information
>1a7s Chain A (length=221) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
IVGGRKARPRQFPFLASIQNQGRHFCGGALIHARFVMTAASCFPGVSTVV
LGAYDLRRRERQSRQTFSISSMSENGYDPQQNLNDLMLLQLDREANLTSS
VTILPLPLQNATVEAGTRCQVAGWGSQRSGGRLSRFPRFVNVTVTPEDQC
RPNNVCTGVLTRRGGICNGDGGTPLVCEGLAHGVASFSLGPCGRGPDFFT
RVALFRDWIDGVLNNPGPGPA
Ligand information
Ligand ID
EOH
InChI
InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3
InChIKey
LFQSCWFLJHTTHZ-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.352
OpenEye OEToolkits 1.7.0
CCO
ACDLabs 11.02
OCC
Formula
C2 H6 O
Name
ETHANOL
ChEMBL
CHEMBL545
DrugBank
DB00898
ZINC
PDB chain
1a7s Chain A Residue 429 [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
1a7s
Atomic resolution structure of human HBP/CAP37/azurocidin.
Resolution
1.12 Å
Binding residue
(original residue number in PDB)
Q94 P220 G221
Binding residue
(residue number reindexed from 1)
Q90 P216 G217
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
S41 D89 N172 G173 D174 G175 G176
Catalytic site (residue number reindexed from 1)
S41 D85 N168 G169 D170 G171 G172
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0004252
serine-type endopeptidase activity
GO:0005515
protein binding
GO:0008201
heparin binding
GO:0008233
peptidase activity
GO:0015643
toxic substance binding
GO:0043395
heparan sulfate proteoglycan binding
Biological Process
GO:0001774
microglial cell activation
GO:0006508
proteolysis
GO:0006935
chemotaxis
GO:0006954
inflammatory response
GO:0007200
phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0008347
glial cell migration
GO:0019730
antimicrobial humoral response
GO:0032724
positive regulation of fractalkine production
GO:0032731
positive regulation of interleukin-1 beta production
GO:0032760
positive regulation of tumor necrosis factor production
GO:0035556
intracellular signal transduction
GO:0035696
monocyte extravasation
GO:0042117
monocyte activation
GO:0042742
defense response to bacterium
GO:0043066
negative regulation of apoptotic process
GO:0043114
regulation of vascular permeability
GO:0045123
cellular extravasation
GO:0045348
positive regulation of MHC class II biosynthetic process
GO:0045785
positive regulation of cell adhesion
GO:0048246
macrophage chemotaxis
GO:0050766
positive regulation of phagocytosis
GO:0050829
defense response to Gram-negative bacterium
GO:0050930
induction of positive chemotaxis
GO:0051607
defense response to virus
GO:0060326
cell chemotaxis
GO:0070944
neutrophil-mediated killing of bacterium
Cellular Component
GO:0005576
extracellular region
GO:0005615
extracellular space
GO:0016020
membrane
GO:0035577
azurophil granule membrane
GO:0035578
azurophil granule lumen
GO:0042582
azurophil granule
GO:0043231
intracellular membrane-bounded organelle
GO:0070062
extracellular exosome
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1a7s
,
PDBe:1a7s
,
PDBj:1a7s
PDBsum
1a7s
PubMed
9761855
UniProt
P20160
|CAP7_HUMAN Azurocidin (Gene Name=AZU1)
[
Back to BioLiP
]