Structure of PDB 6p5a Chain G Binding Site BS07

Receptor Information

>6p5a Chain G (length=442) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ESQQLEESLRKIFTDTQIRILKNGGQRATFNSDDISTAICLHTAGPRAYN
HLYKKGFPLPSRTTLYRWLSDVDIKRGCLDVVIDLMDSDGVDDADKLCVL
AFDEMKVAAAFEYDSSADIVYEPSDYVQLAIVRGLKKSWKQPVFFDFNTR
MDPDTLNNILRKLHRKGYLVVAIVSDLGTGNQKLWTELGISESKTWFSHP
ADDHLKIFVFSDTPHLIKLVRNHYVDSGLTINGKKLTKKTIQEALHLCNK
SDLSILFKINENHINVRSLAKQKVKLATQLFSNTTASSIRRCYSLGYDIE
NATETADFFKLMNDWFDIFNSKLSTSNCIECSQPYGKQLDIQNDILNRMS
EIMRTGILDKPKRLPFQKGIIVNNASLDGLYKYLQENFSMQYILTSRLNQ
DIVEHFFGSMRSRGGQFDHPTPLQFKYRLRKYIIARNTEMLR

Ligand information

Ligand ID

GTP

InChI

InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1

InChIKey

XKMLYUALXHKNFT-UUOKFMHZSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.7.6	c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.370	NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.370	NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
OpenEye OEToolkits 1.7.6	c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
ACDLabs 12.01	O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O

Formula

C10 H16 N5 O14 P3

Name

GUANOSINE-5'-TRIPHOSPHATE

PDB chain

6p5a Chain G Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6p5a Structure of a P element transposase-DNA complex reveals unusual DNA structures and GTP-DNA contacts.
Resolution	3.6 Å
Binding residue (original residue number in PDB)	T405 N410 D528
Binding residue (residue number reindexed from 1)	T278 N283 D401
Annotation score	4

Enzymatic activity

Enzyme Commision number

2.7.7.-

External links

PDB	RCSB:6p5a, PDBe:6p5a, PDBj:6p5a
PDBsum	6p5a
PubMed	31659330
UniProt	Q7M3K2\|PELET_DROME Transposable element P transposase (Gene Name=T)

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