Structure of PDB 8wor Chain B Binding Site BS07

Receptor Information
>8wor Chain B (length=647) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRRDPFDAARGADFDHVYSGVVNLSTENIYSFNYTSQPDQVTAVRVYVNS
SSENLNYPVLVVVRQQKEVLSWQVPLLFQGLYQRSYNYQEVSRTLCPSEA
TNETGPLQQLIFVDVASMAPLGAQYKLLVTKLKHFQLRTNVAFHFTASPS
QPQYFLYKFPKDVDSVIIKVVSEMAYPCSVVSVQNIMCPVYDLDHNVEFN
GVYQSMTKKAAITLQKKDFPGEQFFVVFVIKPEDYACGGSFFIQEKENNL
QRKKNLEVTIVPSIKESVYVKSSLFSVFIFLSFYLGCLLVGFVHYLRFQR
KKYKIYFWNIITIAVFYALPVIQLVITYQTVVNVTGNQDICYYNFLCAHP
LGVLSAFNNILSNLGHVLLGFLFLLIVLRRDILHRRALEPKHFGLFYAMG
IALMMEGVLSACYHVCPNYSNFQFDTSFMYMIAGLCMLKLYQTRHPDINA
SAYSAYASFAVVIMVTVLGVVFGKNDVWFWVIFSAIHVLASLALSTQIYY
MYMDRMVLLVVGNLVNWSFALFGLIYRPRDFASYMLGIFICNLLLYLAFY
IIMKLRSSEKVLPVPLFCIVATAVMWAAALYFFFQNLSSWEGTPAESREK
NRECILLDFFDDHDIWHFLSATALFFSFLVLLTLDDDLDVVRRDQIP
Ligand information
Ligand IDCLR
InChIInChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKeyHVYWMOMLDIMFJA-DPAQBDIFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
CACTVS 3.341CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
ACDLabs 10.04OC4CCC3(C(=CCC2C1C(C(C(C)CCCC(C)C)CC1)(C)CCC23)C4)C
OpenEye OEToolkits 1.5.0CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
CACTVS 3.341CC(C)CCC[CH](C)[CH]1CC[CH]2[CH]3CC=C4C[CH](O)CC[C]4(C)[CH]3CC[C]12C
FormulaC27 H46 O
NameCHOLESTEROL
ChEMBLCHEMBL112570
DrugBankDB04540
ZINCZINC000003875383
PDB chain8wor Chain B Residue 913 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8wor Structural insights into cholesterol transport and hydrolase activity of a putative human RNA transport protein SIDT1.
Resolution2.66 Å
Binding residue
(original residue number in PDB)		F702 F705 R712 D713 S716 Y717 G720 L763
Binding residue
(residue number reindexed from 1)		F519 F522 R529 D530 S533 Y534 G537 L580
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:8wor, PDBe:8wor, PDBj:8wor
PDBsum8wor
PubMed38378654
UniProtQ9NXL6|SIDT1_HUMAN SID1 transmembrane family member 1 (Gene Name=SIDT1)

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