Structure of PDB 5oc9 Chain B Binding Site BS07

Receptor Information
>5oc9 Chain B (length=616) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYEQET
LENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDD
NNDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLT
SGIVIQVFPLHDSEALKKLEDTWYLKYQPIDSIRGYFGETIALYFGFLEY
FTFALIPMAVIGLPYYLFVWEDYDKYVIFASFNLIWSTVILELWKRGCAN
MTYRWGTLLMKRKFEEPRPGFHGVLGINSITGKEEPLYPSYKRQLRIYLV
SLPFVCLCLYFSLYVMMIYFDMEVWALGLHWTSVLLYVPSIIYAIVIEIM
NRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVL
KDMKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQALKAD
IDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAV
LNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCAL
IGMSPQVNAVFPESKADLILIVVAVEHALLALKFILAFAIPDKPRHIQMK
LARLEFESLEALKQQQ
Ligand information
Ligand ID79M
InChIInChI=1S/C19H36O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(22)23-17-18(21)16-20/h9-10,18,20-21H,2-8,11-17H2,1H3/b10-9-/t18-/m1/s1
InChIKeyOWGMAJRKMYGYBQ-HJCTWCACSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.9.2CCCCCCCC/C=C\CCCCCC(=O)OC[C@@H](CO)O
ACDLabs 12.01O=C(OCC(O)CO)CCCCC\C=C/CCCCCCCC
CACTVS 3.385CCCCCCCCC=CCCCCCC(=O)OC[CH](O)CO
CACTVS 3.385CCCCCCCC\C=C/CCCCCC(=O)OC[C@H](O)CO
OpenEye OEToolkits 1.9.2CCCCCCCCC=CCCCCCC(=O)OCC(CO)O
FormulaC19 H36 O4
Name(2R)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate;
[(2R)-2,3-bis(oxidanyl)propyl] (Z)-hexadec-7-enoate
ChEMBL
DrugBank
ZINCZINC000098208566
PDB chain5oc9 Chain B Residue 710 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5oc9 The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		L557 E560
Binding residue
(residue number reindexed from 1)		L534 E537
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005227 calcium-activated cation channel activity
GO:0005229 intracellularly calcium-gated chloride channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5oc9, PDBe:5oc9, PDBj:5oc9
PDBsum5oc9
PubMed31477691
UniProtQ9NW15|ANO10_HUMAN Anoctamin-10 (Gene Name=ANO10)

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