Structure of PDB 7z2z Chain A Binding Site BS07

Receptor Information
>7z2z Chain A (length=1431) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKAN
GALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQ
ILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQ
RRCLHCGALNGVVKKAAAGAGSAALKIIHDTFRWVGKKSAPEKDIWVGEW
KEVLAHNPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSG
RPETYIWRYLPAPPVCIRPSVMSNEDDLTVKLTEIVWTSSLIKAGLDKGI
SINNMMEHWDYLQLTVAMYINSDSVNPAMLPGSKPIRGFCQRLKGKQGRF
RGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEKVTRYNRH
KLQELIVNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVVER
HLEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTPYNADFDG
DEMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDFITGSYLI
SHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTGKQVFSLLI
KPNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQILSGVM
DKSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSIGI
NDVTPADDLKQKKEELVEIAYHKCDELITLFNKGELETQPGCNEEQTLEA
KIGGLLSKVREEVGDVCINELDNWNAPLIMATCGSKGSTLNVSQMVAVVG
QQIISGNRVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGLSPPEFLFH
AISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRTSANGIVQF
TYGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPYAIMETAN
EILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHSLREYING
KATALANLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRISE
KSVRKFLEIALFKYRKARLEPGTAIGAIGAQSIGEPGTQMTLKTFHFAGV
ASMNVTLGVPRIKEIINASKVISTPIINAVLVNDNDERAARVVKGRVEKT
LLSDVAFYVQDVYKDNLSFIQVRIDLGTIDKLQLELTIEDIAVAITRASK
LKIQASDVNIIGKDRIAINVFPSENDVFYRMQQLRRALPDVVVKGLPDIS
RAVINIRDDGKRELLVEGYGLRDVMCTDGVIGSRTTTNHVLEVFSVLGIE
AARYSIIREINYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKM
RDSVLQLASFEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMSIGTGSFK
VVKGTNISEKDLVPKRCLFESLSNEAALKAN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain7z2z Chain A Residue 1503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7z2z Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration.
Resolution3.07 Å
Binding residue
(original residue number in PDB)		D511 D513 D515
Binding residue
(residue number reindexed from 1)		D497 D499 D501
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7z2z, PDBe:7z2z, PDBj:7z2z
PDBsum7z2z
PubMed36977686
UniProtP04051|RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 (Gene Name=RPO31)

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