Structure of PDB 7yw2 Chain A Binding Site BS07

Receptor Information
>7yw2 Chain A (length=206) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQDRNVQLSKALSYALRHGALKLGLPMRADGFVPLQALLQLPQFHSFSIE
DVQLVVNTNEKQRFTLQPGEPSTGLLIRANQGHSLQVPELELTPLETPQA
LPLTLVHGTFWKHWPSILLKGLSRQGRTHIHLASGLPGDPGVISGIRPNC
EVAVFIDGPLALTDGIPFFCSANGVILTPGNAEGFLLPKYFKEALQLRPT
RKPLSL
Ligand information
Ligand IDSOR
InChIInChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
InChIKeyFBPFZTCFMRRESA-JGWLITMVSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C([C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O
CACTVS 3.341OC[CH](O)[CH](O)[CH](O)[CH](O)CO
ACDLabs 10.04OC(C(O)CO)C(O)C(O)CO
CACTVS 3.341OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
OpenEye OEToolkits 1.5.0C(C(C(C(C(CO)O)O)O)O)O
FormulaC6 H14 O6
Namesorbitol;
D-sorbitol;
D-glucitol
ChEMBLCHEMBL1682
DrugBankDB01638
ZINCZINC000018279893
PDB chain7yw2 Chain A Residue 313 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7yw2 Structural and biochemical insights into the molecular mechanism of TRPT1 for nucleic acid ADP-ribosylation.
Resolution2.23 Å
Binding residue
(original residue number in PDB)		H36 S102 G144
Binding residue
(residue number reindexed from 1)		H18 S84 G126
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.1.160: 2'-phosphotransferase.
Gene Ontology
Molecular Function
GO:0000215 tRNA 2'-phosphotransferase activity
GO:0016740 transferase activity
Biological Process
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0008033 tRNA processing
Cellular Component
GO:0005575 cellular_component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7yw2, PDBe:7yw2, PDBj:7yw2
PDBsum7yw2
PubMed37334830
UniProtQ8K3A2|TRPT1_MOUSE tRNA 2'-phosphotransferase 1 (Gene Name=Trpt1)

[Back to BioLiP]