Structure of PDB 5iu9 Chain A Binding Site BS07

Receptor Information
>5iu9 Chain A (length=417) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VFNLKYTVEEELRAGTKIANVTADAKVAGFAPYLRVISNSEPRWVNLSPA
GLLITKQKIDRDAVCRQTPKCFISLEVMSNSMEICVIKIEIIDVNDNAPR
FPTNHIDIEISENAAPGTRFPLEGASDPDSGSNGIQTYTITPNDIFGLEI
KTRGDGSKIAELVVEKTLDRETQSRYTFELTAEDGGDPPKSGTVQLNIKV
IDSNDNNPVFDEPVYTVNVLENSPINTLVIDLNATDPDEGTNGEVVYSFI
NFVSNLTKQMFKIDPKTGVITVNGVLDHEELHIHEIDVQAKDLGPNSIPA
HCKVIVNVIDINDNAPEIKLLSENSEMVEVSENAPLGYVIALVRVSDNDS
GANGKVQCRLQGNVPFRLNEFESFSTLLVDGRLDREQRDMYNLTILAEDS
GYPPLRSSKSFAVKVTD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5iu9 Chain A Residue 1007 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5iu9 Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy.
Resolution3.59 Å
Binding residue
(original residue number in PDB)		E226 D282 E284 D318 N319
Binding residue
(residue number reindexed from 1)		E221 D277 E279 D313 N314
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5iu9, PDBe:5iu9, PDBj:5iu9
PDBsum5iu9
PubMed27787195
UniProtF8W3X3|PCD19_DANRE Protocadherin-19 (Gene Name=pcdh19)

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