Structure of PDB 5dzx Chain A Binding Site BS07

Receptor Information

>5dzx Chain A (length=414) Species: 10090 (Mus musculus)

IRYSIPEETESGYLVAHLAKDLGFRVGELATRRARIHHRGNKELLQLDVE
TGNLLLKEKPDREALCGATEPCVLHFQIILENPVQFFQTELQLTDINDHS
PEFPDTEMLLKIQESTQPATVFLLKAAQDSDIGSNAVQNYTVSPNLHFHV
VTLSRSDGRKYPELVLDRALDREEQPELTLILTALDGGAPPKSGTTTVRI
EVVDINDNAPEFVQSLYSVEVPENSPLDALVVTVSARDLDAGIHGNVAYS
LFQGGGGPQPFVIDEITGEIRLKGALDFEATSYYTMEIVATDSGGLSGKC
TVAIQVLDVNDNAPKLTISSLTSSIPENAPEAVVAVFSVSDPDSGDNGRM
VCSIQNELPFLLKPTFENYYTLAAEGPLDREIREEYNITIIVSDLGTPRL
TTQHTITVQVVDIN

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5dzx Chain A Residue 518

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5dzx Structural Basis of Diverse Homophilic Recognition by Clustered alpha- and beta-Protocadherins.
• Resolution: 2.879 Å
• Binding residue (original residue number in PDB): E225 D279 E281 D313
• Binding residue (residue number reindexed from 1): E223 D277 E279 D311
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5dzx, PDBe:5dzx, PDBj:5dzx
• PDBsum: 5dzx
• PubMed: 27161523
• UniProt: Q91XZ4|PCDB6_MOUSE Protocadherin beta-6 (Gene Name=Pcdhb6)