Structure of PDB 5b2p Chain A Binding Site BS07

Receptor Information
>5b2p Chain A (length=1455) Species: 401614 (Francisella tularensis subsp. novicida U112) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNFKILPIAIDLGVKNTGVFSAFYQKGTSLERLDNKNGKVYELSKDSYTL
LMNNRTARRHQRRGIDRKQLVKRLFKLIWTEQLNLEWDKDTQQAISFLFN
RRGFSFITDGYSVKAILMDIFDDYNGEDDSYLKLATEQESKISEIYNKLM
QKILEFKLMKLCTDIKDDTLKEITSYEFELLADYLANYSESLKTQKFYNI
QEFLKRHATINDRILDTLLTDDLDIWNFNFELHHFVFAVNKIKSEMASGG
RHRSQYFQEITNVLDENNHQEGYLKNFCENLHNKKYSNLSVKNLVNLIGN
LSNLELKPLRKYFNDKIHAKADHWDEQKFTETYCHWILGEWRVGVKDQDK
KDGAKYSYKDLCNELKQKVTKAGLVDFLLELDPCRTIPPYLDNNNRKPPK
CQSLILNPKFLDNQYPNWQQYLQELKKLQSIQNYLDSFETDLKVLKSSKD
QPYFVEYKSSNQQIASGQRDYKDLDARILQFIFDRVKASDELLLNEIYFQ
AKKLKQESSKKLDEVIANSQLSQILKSQHTNGIFEQGTFLHLVCKYYKQR
QRARDSRLYIMPEYRYDKKLHKYNNTGRFDDDNQLLTYCNHKPRQKRYQL
LNDLAGVLQVSPNFLKDKIGSDDDLFISKWLVEHIRGFKKACEDSLKIQK
DNRGLLNHKINIARNTKGKCEKEIFNLICKIEGYKHGLAYELGVLLFGEP
NEASKPEFDRKIKKFNSIYSFAQIQQIAFAERKGNANTCAVCSADNAHRM
QQIKIILSAKAQRLPAIPTRIVDGAVKKMATILAKNIVDDNWQNIKQVLS
AKHQLHIPIITESNAFEFEPALADVKGKSLKDRRKKALERISPENIFKDK
NNRIKEFAEELDHIIPRTLNDEANLICVTGNRIFCLRDNYRSFINLTPQE
QKAFRHALFLADENPIKQAVIRAINNRNRTFVNGTQRYFAEVLANNIYLR
AKKENLNTDKISFDYFGIPTIGNGRGIAEIRQLYEKVDSDIQAYAKGDKP
QASYSHLIDAMLAFCIAADEHRNDGSIGLEIDKNYSLYPDIFSQIKITDN
EFSDKKLVRKKAIEGFNTHRQMTRDGIYAENYLPILIHKELNEVRKGYTW
KNSEEIKIFKGKKYDIQQLNNLVYCLKFVDKPISIDIQISTLEELRNILT
TNNIAATAEYYYINLKTQKLHEYYIENYNTALGYKKYSKEMEFLRSLAYR
SERVKIKSIDDVKQVLDKDSNFIIGKITLPFKKEWQRLYREWQNTTIKDD
YEFLKSFFNVKSITKLHKKVRKDFSLPISTNEGKFLVKRKTWDNNFIYQI
LNDSDSRADGTKPFIPAFDISKNEIVEAIIDSFTSKNIFWLPKNIELQKV
DNKNIFAIDTSKWFEVETPSDLRDIGIATIQYKIDNNSRPKVRVKLDYVI
DDDSKINYFMNHSLLKSRYPDKVLEILKQSTIIEFESSGFNKTIKEMLGM
KLAGI
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5b2p Chain A Residue 1715 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5b2p Structure and Engineering of Francisella novicida Cas9
Resolution1.7 Å
Binding residue
(original residue number in PDB)		E1231 N1234 I1497 D1498 S1499
Binding residue
(residue number reindexed from 1)		E1064 N1067 I1330 D1331 S1332
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5b2p, PDBe:5b2p, PDBj:5b2p
PDBsum5b2p
PubMed26875867
UniProtA0Q5Y3|CAS9_FRATN CRISPR-associated endonuclease Cas9 (Gene Name=cas9)

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