Structure of PDB 4xpt Chain A Binding Site BS07

Receptor Information
>4xpt Chain A (length=535) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLA
VGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVGFYY
NVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFEVGHVEGFQSAASE
YFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKV
VWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAA
TQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIF
SVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMML
ATLGLDSSFGGMEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCT
QGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFP
PGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIA
GSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain4xpt Chain A Residue 611 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4xpt Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Resolution3.36 Å
Binding residue
(original residue number in PDB)		A44 D46 N49 S320 N352
Binding residue
(residue number reindexed from 1)		A20 D22 N25 S256 N288
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4xpt, PDBe:4xpt, PDBj:4xpt
PDBsum4xpt
PubMed25970245
UniProtQ7K4Y6|DAT_DROME Sodium-dependent dopamine transporter (Gene Name=DAT)

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