Structure of PDB 4lhd Chain A Binding Site BS07

Receptor Information
>4lhd Chain A (length=952) Species: 1111708 (Synechocystis sp. PCC 6803 substr. Kazusa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AIAVDLTKLEEKLAPADSFLDRHLGPGETEQRQMLQTLGFDTLGDLIDQA
VPPAIRFPRSLQLPASQSEYGAIAQLKSIASKNQVFRSYIGMGYYDTITP
PVIQRNILENPGWYTAYTPYQAEIAQGRLEALLNFQTMVMDLTGLEIANA
SLLDEGTAAAEAMALSYGVSKSKANAFFVAQDCHPQTIEVIKTRANPLGI
EVIVGDHHTFSFSTSIFGALLQYPATDGAVYDYRSFIDKAHQHQALVTLA
ADPLSLTLLTPPGELGADIAVGSTQRFGIPLGYGGPHAAYFATKAEYQRK
MPGRIVGVSKDAHGNPALRLALQTREQHIRRDKATSNICTAQVLLAVMAS
MYGVYHGSTGLKNIALRIHQLTVLLAIGLKRLNYSLNNDYFFDTLRVGVG
EQSAPAILKAAEGRGINLRPLVPGEVGISLDETVTVQDLLDLWQVFAGKD
NLPFTPEELWSEVKTSFPADLTRQSLYLQDAVFNQYHSETELLRYLHQLE
SKDLALNTSMIPLGSCTMKLNATAEMMPVTWPEFGKIHPFAPAGQTEGYQ
ILFAQLEAWLGEITGFDAISLQPNAGSQGEYAGLQVIRQYHLSRGEEQRN
ICLIPESAHGTNPASAVMCGMQVVPVKCDGEGNIDVEDLTSKAEKYGDRL
AALMVTYPSTHGVFEATIGTICDIVHRFGGEVYMDGANMNAQVGLCRPAD
FGADVCHLNLHKTFCIPHGGGGPGMGPIGVKSHLQAFLPRTDQSIGMISA
APYGSASILVISWMYIAMMGPQGLTKATEVAILSANYMAKRLENYYPILF
RGNNELVAHECILDLRPLKKQAAIEVEDVAKRLMDFGFHAPTVSWPVLGT
MMVEPTESESLGELDRFCDAMIAIYQEAQAITHGEIDPADNPLKNAPHTA
QSLICGEWNHPYSQEEAAYPAPWTKQFKFWPAVGRINNTYGDRHLVCSCE
GM
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain4lhd Chain A Residue 1009 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4lhd Structure of the Homodimeric Glycine Decarboxylase P-protein from Synechocystis sp. PCC 6803 Suggests a Mechanism for Redox Regulation.
Resolution1.7959 Å
Binding residue
(original residue number in PDB)		Q76 L77 P78 W573
Binding residue
(residue number reindexed from 1)		Q62 L63 P64 W559
Annotation score1
Enzymatic activity
Enzyme Commision number 1.4.4.2: glycine dehydrogenase (aminomethyl-transferring).
Gene Ontology
Molecular Function
GO:0004375 glycine dehydrogenase (decarboxylating) activity
GO:0016491 oxidoreductase activity
GO:0016594 glycine binding
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006544 glycine metabolic process
GO:0006546 glycine catabolic process
GO:0019464 glycine decarboxylation via glycine cleavage system
Cellular Component
GO:0005829 cytosol
GO:0005960 glycine cleavage complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4lhd, PDBe:4lhd, PDBj:4lhd
PDBsum4lhd
PubMed24121504
UniProtP74416|GCSP_SYNY3 Glycine dehydrogenase (decarboxylating) (Gene Name=gcvP)

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