Structure of PDB 5j8b Chain z Binding Site BS06

Receptor Information
>5j8b Chain z (length=671) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKVILLEPLENLGDVGQVVDVKPGYARNYLLPRGLAVLATESNLKALEAR
IRAQAKRLAERKAEAERLKEILENLSRIRNFSIIAHVDHGKSTLADRILE
LTHAVSDREMREQFLDSLELERERGITIKASAVRVTYRAKDGEEYVFHLI
DTPGHVDFTYEVSRALAAVEGVLLVVDASQGVEAETLAKFYMALEHGHVI
IPVINKIDLPNARPLEVALEVEEVLGLPADEAIFASGKTGEGVEEILEAI
VQRIPPPKGDPEAPLKALIFDSVYDAYQGVIPYLRLFEGRVRPGDRIRIY
STGKEFTVDKVGVFTPQGLVATEALEAGEVGWLVAAIRDIHDVQVGDTIT
LADRPTPSPYPGFRPAKPVVFAGLYPVDSGDYGKLRDALEKLKLNDAALT
FEPESSTALGFGFRCGFLGLLHAEIVQERLEREFGLSLIATAPSVVYKVR
LKSGEEVEVHNPADLPDPTRIEEILEPYVKLTIFTPEEYVGSLMQLLQEK
RGRLVNMNYLPGAQKRVELVYEAPFAEILYDFHDRLKSVSRGYASMDYEQ
AGYRPGDLVKVNVLVHGEVVDALTFIAHREKAYTMARAIVDKLAEVIPRQ
LFEVPIQAAIGGKIIARATVKALRKDVLAKCYGGDVTRKKKLLEKQKEGK
KRLKAIGKVEVPQEAFLAVLS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5j8b Chain z Residue 702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5j8b Elongation factor 4 remodels the A-site tRNA on the ribosome.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		S23 T58
Binding residue
(residue number reindexed from 1)		S92 T127
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K22 S23 T58 H86
Catalytic site (residue number reindexed from 1) K91 S92 T127 H155
Enzyme Commision number 3.6.5.-
3.6.5.n1: elongation factor 4.
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0043022 ribosome binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0045727 positive regulation of translation
Cellular Component
GO:0005840 ribosome
GO:0005886 plasma membrane

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5j8b, PDBe:5j8b, PDBj:5j8b
PDBsum5j8b
PubMed27092003
UniProtQ5SKA7|LEPA_THET8 Elongation factor 4 (Gene Name=lepA);
Q5SLQ1|RL9_THET8 Large ribosomal subunit protein bL9 (Gene Name=rplI)

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