Structure of PDB 8a7e Chain Q Binding Site BS06

Receptor Information
>8a7e Chain Q (length=1524) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRALYFSGRGEQLRLRADLELPRDAFTLQVWLRAEGGQRSPAVITGLYDK
CSYISRDRGWVVGIHTISDQDNKDPRYFFSLKTDRARQVTTINAHRSYLP
GQWVYLAATYDGQFMKLYVNGAQVATSGEQVGGIFSPLTQKCKVLMLGGS
ALNHNYRGYIEHFSLWKVARTQREILSDMETHGAHTALPQLLLQENWDNV
KHAWSPMKDGSSPKVEFSNAHGFLLDTSLEPPLCGQTLCDNTEVIASYNQ
LSSFRQPKVVRYRVVNLYEDDHKNPTVTREQVDFQHHQLAEAFKQYNISW
ELDVLEVSNSSLRRRLILANCDISKIGDENCDPECNHTLTGHDGGDCRHL
RHPAFVKKQHNGVCDMDCNYERFNFDGGECCDPEITNVTQTCFDPDSPHR
AYLDVNELKNILKLDGSTHLNIFFAKSSEEELAGVATWPWDKEALMHLGG
IVLNPSFYGMPGHTHTMIHQIGHSLGLYHVFRGISEIQSCSDPCMETEPS
FETGDLCNDTNPAPKHKSCGDPGPGNDTCGFHSFFNTPYNNFMSYADDDC
TDSFTPNQVARMHCYLDLVYQGWQPSRKPAPVALAPQVLGHTTDSVTLEW
FPPIDGHFFERELGSACHLCLEGRILVQYASNASSPMPCSPSGHWSPREA
EGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQGCYLELEFLYPLVP
ESLTIWVTFVSTDWDSSGAVNDIKLLAVSGKNISLGPQNVFCDVPLTIRL
WDVGEEVYGIQIYTLDEHLEIDAAMLTSTADTPLCLQCKPLKYKVVRDPP
LQMDVASILHLNRKFVDMDLNLGSVYQYWVITISGTEESEPSPAVTYIHG
SGYCGDGIIQKDQGEQCDDMNKINGDGCSLFCRQEVSFNCIDEPSRCYFH
DGDGVCEEFEQKTSIKDCGVYTPQGFLDQWASNASVSHQDQQCPGWVIIG
QPAASQVCRTKVIDLSEGISQHAWYPCTISYPYSQLAQTTFWLRAYFSQP
MVAAAVIVHLVTDGTYYGDQKQETISVQLLDTKDQSHDLGLHVLSCRNNP
LIIPVVHDLSQPFYHSQAVRVSFSSPLVAISGVALRSFDNFDPVTLSSCQ
RGETYSPAEQSCVHFACEKTDCPELAVENASLNCSSSDRYHGAQCTVSCR
TGYVLQIRRDDELIKSQTGPSVTVTCTEGKWNKQVACEPVDCSIPDHHQV
YAASFSCPEGTTFGSQCSFQCRHPAQLKGNNSLLTCMEDGLWSFPEALCE
LMCLAPPPVPNADLQTARCRENKHKVGSFCKYKCKPGYHVPGSSRKSKKR
AFKTQCTQDGSWQEGACVPVTCDPPPPKFHGLYQCTNGFQFNSECRIKCE
DSDASQGLGSNVIHCRKDGTWNGSFHVCQEMQGQCSVPNELNSNLKLQCP
DGYAIGSECATSCLDHNSESIILPMNVTVRDIPHWLNPTRVERVVCTAGL
KWYPHPALIHCVKGCEPFMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKV
TPFPMSCDLQGDCACRDPQAQEHS
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8a7e Chain Q Residue 1706 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8a7e Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism.
Resolution5.02 Å
Binding residue
(original residue number in PDB)		K451 N454 V456 D458 C461 D469 E472
Binding residue
(residue number reindexed from 1)		K358 N361 V363 D365 C368 D376 E379
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.79: pappalysin-1.
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0007166 cell surface receptor signaling pathway
GO:0007565 female pregnancy
GO:0030163 protein catabolic process
GO:0032354 response to follicle-stimulating hormone
GO:0071548 response to dexamethasone
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8a7e, PDBe:8a7e, PDBj:8a7e
PDBsum8a7e
PubMed36257932
UniProtQ13219|PAPP1_HUMAN Pappalysin-1 (Gene Name=PAPPA)

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