Structure of PDB 7tf6 Chain N Binding Site BS06

Receptor Information

>7tf6 Chain N (length=438) Species: 1280 (Staphylococcus aureus)

TFTKEDIRKFAEEENVRYLRLQFTDILGTIKNVEVPVSQLEKVLDNEMMF
DGSSIEGFVRIEESDMYLHPDLDTWVIFPWGKVARLICDVYKTDGTPFEG
DPRANLKRVLKEMEDLGFTDFNLGPEPEFFLFKLDEKGEPTLELNDDGGY
FDLAPTDLGENCRRDIVLELEDMGFDIEASHHEVAPGQHEIDFKYADAVT
ACDNIQTFKLVVKTIARKHNLHATFMPKPLFGVNGSGMHFNVSLFKGKEN
AFFDPNTEMGLTETAYQFTAGVLKNARGFTAVCNPLVNSYKRLVPGYEAP
CYIAWSGKNRSPLIRVPSSRGLSTRIEVRSVDPAANPYMALAAILEAGLD
GIKNKLKVPEPVNQNIYEMNREEREAVGIQDLPSTLYTALKAMRENEVIK
KALGNHIYNQFINSKSIEWDYYRTQVSEWERDQYMKQY

Ligand information

• Ligand ID: GLN
• InChI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
• InChIKey: ZDXPYRJPNDTMRX-VKHMYHEASA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C(CC(=O)N)C(C(=O)O)N
  OpenEye OEToolkits 1.5.0: C(CC(=O)N)[C@@H](C(=O)O)N
  ACDLabs 10.04: O=C(N)CCC(N)C(=O)O
  CACTVS 3.341: N[CH](CCC(N)=O)C(O)=O
  CACTVS 3.341: N[C@@H](CCC(N)=O)C(O)=O
• Formula: C5 H10 N2 O3
• Name: GLUTAMINE
• ChEMBL: CHEMBL930
• DrugBank: DB00130
• ZINC: ZINC000001532526
• PDB chain: 7tf6 Chain N Residue 503

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7tf6 Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
• Resolution: 2.15 Å
• Binding residue (original residue number in PDB): E136 E191 G243 H247 R300 E306
• Binding residue (residue number reindexed from 1): E128 E183 G235 H239 R292 E298
• Annotation score: 5

Enzymatic activity

• Enzyme Commision number: 6.3.1.2: glutamine synthetase.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004356 glutamine synthetase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006542 glutamine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7tf6, PDBe:7tf6, PDBj:7tf6
• PDBsum: 7tf6
• PubMed: 35778410
• UniProt: E3VXC2