Structure of PDB 8imy Chain G Binding Site BS06

Receptor Information
>8imy Chain G (length=581) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRALARLVLRLNAPLCVLSYVAGIAWFLALVFPPLTQRTYMSENAMGSTM
VEEQFAGGDRARAFARDFAAHRKKSGALPVAWLERTMRSVGLEVYTQSFS
RKLPFPDETHERYMVSGTNVYGILRAPRAASTESLVLTVPCGSDSTNSQA
VGLLLALAAHFRGQIYWAKDIVFLVTEHDLLGTEAWLEAYHDVNVTGMQS
SPLQGRAGAIQAAVALELSSDVVTSLDVAVEGLNGQLPNLDLLNLFQTFC
QKGGLLCTLQGKLQPEDWDGPLQGLQTLLLMVLRQASGRPHGSHGLFLRY
RVEALTLRGINSFRQYKYDLVAVGKALEGMFRKLNHLLERLHQSFFLYLL
PGLSRFVSIGLYMPAVGFLLLVLGLKALELWMQLHEGVGLASLVAPLLIS
QAMGLALYVLPVLGQHVATQHFPVAEAEAVVLTLLAIYAAGLALPHNTHR
PDRGWMALKLVALIYLALQLGCIALTNFSLGFLLATTMVPTAALAKPHGP
RTLYAALLVLTSPAATLLGSLFLWRELQEAPLSLAEGWQLFLAALAQGVL
EHHTYGALLFPLLSLGLYPCWLLFWNVLFWK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8imy Chain G Residue 1813 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8imy Structures of substrates- and products-bound glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis
Resolution3.22 Å
Binding residue
(original residue number in PDB)		H354 Q355
Binding residue
(residue number reindexed from 1)		H342 Q343
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003923 GPI-anchor transamidase activity
GO:0005515 protein binding
GO:0015631 tubulin binding
GO:0034235 GPI anchor binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006506 GPI anchor biosynthetic process
GO:0006621 protein retention in ER lumen
GO:0008218 bioluminescence
GO:0016255 attachment of GPI anchor to protein
GO:0065003 protein-containing complex assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005813 centrosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0042765 GPI-anchor transamidase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8imy, PDBe:8imy, PDBj:8imy
PDBsum8imy
PubMed37684232
UniProtO43292|GPAA1_HUMAN Glycosylphosphatidylinositol anchor attachment 1 protein (Gene Name=GPAA1)

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