Structure of PDB 4gfh Chain F Binding Site BS06

Receptor Information
>4gfh Chain F (length=1098) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SASDKYQKISQLEHILKRPDTYIGSVETQEQLQWIYDEETDCMIEKNVTI
VPGLFKIFDEILVNAADNKVRDPSMKRIDVNIHAEEHTIEVKNDGKGIPI
EIHNKENIYIPEMIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEF
ILETADLNVGQKYVQKWENNMSICHPPKITSYKKGPSYTKVTFKPDLTRF
GMKELDNDILGVMRRRVYDINGSVRDINVYLNGKSLKIRNFKNYVELYLK
SLIPTILYERINNRWEVAFAVSDISFQQISFVNSIATTMGGTHVNYITDQ
IVKKISEILKKKKKKSVKSFQIKNNMFIFINCLIENPAFTSQTKEQLTTR
VKDFGSRCEIPLEYINKIMKTDLATRMFEIASRITNYPKLEDANKAGTKE
GYKCTLVLTEGDSALSLAVAGLAVVGRDYYGCYPLRGKMLNVREASADQI
LKNAEIQAIKKIMGLQHRKKYEDTKSLRYGHLMIMTDQDHDGSHIKGLII
NFLESSFPGLLDIQGFLLEFITPIIKVSITKPTKNTIAFYNMPDYEKWRE
EESHKFTWKQKYYTSLAQEVREYFSNLDRHLKIFHSLQGNDKDYIDLAFS
KKKADDRKEWLRQYEPGTVLDPTLKEIPISDFINKELILFSLADNIRSIP
NVLDGFKPGQRKVLYGCFKKNLKSELKVAQLAPYVSECTAYHHGEQSLAQ
TIIGLAQNFVGSNNIYLLLPNGAFGTRATGGKDAAAARYIYTELNKLTRK
IFHPADDPLYKYIQEDEKTVEPEWYLPILPMILVNGAEGIGTGWSTYIPP
FNPLEIIKNIRHLMNDEELEQMHPWFRGWTGTIEEIEPLRYRMYGRIEQI
GDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHDDNIKF
IITLSPEEMAKTRKIGFYERFKLISPISLMNMVAFDPHGKIKKYNSVNEI
LSEFYYVRLEYYQKRKDHMSERLQWEVEKYSFQVKFIKMIIEKELTVTNK
PRNAIIQELENLGFPRFNKEGKPYYGSEELYGTYEYLLGMRIWSLTKERY
QKLLKQKQEKETELENLLKLSAKDIWNTDLKAFEVGYQEFLQRDAEAR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4gfh Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity.
Resolution4.408 Å
Binding residue
(original residue number in PDB)		K477 M478 L479 N480 H533 R650 K651 R781 Y782 I833 G834 T835 G836 W837 S838 K965 P969 N974
Binding residue
(residue number reindexed from 1)		K438 M439 L440 N441 H494 R607 K608 R738 Y739 I790 G791 T792 G793 W794 S795 K922 P926 N931
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4gfh, PDBe:4gfh, PDBj:4gfh
PDBsum4gfh
PubMed23022727
UniProtP06786|TOP2_YEAST DNA topoisomerase 2 (Gene Name=TOP2)

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