Structure of PDB 7n2c Chain EF Binding Site BS06

Receptor Information
>7n2c Chain EF (length=685) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SARTTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHGITITS
AATTAFWSGMAKQYEPHRINIIDTPGHVDFTIEVERSMRVLDGAVMVYCA
VGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANFLKVVNQIKTRLGAN
PVPLQLAIGAEEHFTGVVDLVKMKAINWNDADQGVTFEYEDIPADMVELA
NEWHQNLIESAAEASEELMEKYLGGEELTEAEIKGALRQRVLNNEIILVT
CGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILDDGKDTPAERHASDDE
PFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKAARERFGRIVQ
MHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDPDAPIILERMEFPEPV
ISIAVEPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELH
LDIIVDRMKREFNVEANVGKPQVAYRETIRQKVTDVEGKHAKQSGGRGQY
GHVVIDMYPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQLKAGP
LAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLEP
IMKVEVETPEENTGDVIGDLSRRRGMLKGQESEVTGVKIHAEVPLSEMFG
YATQLRSLTKGRASYTMEFLKYDEAPSNVAQAVIE
Ligand information
Ligand IDGDP
InChIInChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H15 N5 O11 P2
NameGUANOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL384759
DrugBankDB04315
ZINCZINC000008215481
PDB chain7n2c Chain EF Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7n2c Structural basis of early translocation events on the ribosome.
Resolution2.72 Å
Binding residue
(original residue number in PDB)		D20 G22 K23 T24 T25 N142 K143 D145 S268 F270
Binding residue
(residue number reindexed from 1)		D20 G22 K23 T24 T25 N127 K128 D130 S253 F255
Annotation score4
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0032790 ribosome disassembly
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7n2c, PDBe:7n2c, PDBj:7n2c
PDBsum7n2c
PubMed34234344
UniProtP0A6M8|EFG_ECOLI Elongation factor G (Gene Name=fusA)

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