Structure of PDB 7mqr Chain E Binding Site BS06

Receptor Information

>7mqr Chain E (length=823) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDICPGTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEG
LCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVN
FSFCQDLHHKCKNSRCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPC
PKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANL
GLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIA
LKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYK
EAPYQNVTEFSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVK
TLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKP
PSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRQILKELEESSF
RKTFEDYLHNVVFVPREEHRPFEKVVNKESLVISGLRHFTGYRIELQACN
QDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKE
PNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIR
ATSLAGNGSWTEPTYFYVTDYLD

Ligand information

>7mqr Chain H (length=16) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

HLCGSELVEALYLVCL

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	7mqr Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Resolution	4.1 Å
Binding residue (original residue number in PDB)	R479 K484 R554
Binding residue (residue number reindexed from 1)	R471 K476 R537

Enzymatic activity

Enzyme Commision number

2.7.10.1: receptor protein-tyrosine kinase.

External links

PDB	RCSB:7mqr, PDBe:7mqr, PDBj:7mqr
PDBsum	7mqr
PubMed	35289328
UniProt	P06213\|INSR_HUMAN Insulin receptor (Gene Name=INSR)

[Back to BioLiP]