Structure of PDB 7lo5 Chain D Binding Site BS06

Receptor Information
>7lo5 Chain D (length=1012) Species: 980427 (Deinococcus wulumuqiensis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSLQLVKKFQKRLEDIVAYGGTRNESSVRAAFQQLLSDWAEGSGLRLITE
VTQKAVAGNNVRPDGTLKDSLQQSRGYWESKDEADTLDDEIQKKLAKGYP
RDNIIFEDSRLAVLMQNGEEVQRVDMGDAGALAGLLKLFFEFEPPQVLEF
RKAVDHFKDEMPHLLKILREAADAAEQKADYRGERDHFVEIAKEAINPDF
SPRDAREMLIQHILTGDLFTSVFDNAQYHEDNNIAQQLQQLAATFYKGPV
KRDIAERTKRYYGAIQAAAAQIADHHEKQRFLKALYENFYRAYNPAGAER
LGIFYTPGEIVRFMIEATDTLLEKHFQKELADKGVEILDPATGTGTFITE
LIDFLPKAKLEQKYREELHCNELALLPYYIANLNIEATYAQKMGRYEEFR
NIVLVDTLDNTSGLFGSVTAENLERAKRQNARPVRVIIGNPPYRANQANE
NDNNKNREYKEIDRRIKATYVAASTAQKTKLYDMYSRFLRWATDRLKEDG
IVAFVSNSSFIDSRTFDGFRKEVVKDFDHIYILDMKGNANTSGERRKREG
GNVFNDQIKVGVAVYFLVRSAKDTKIWYHAVPDFWRAREKLEWLKTTKFE
DIEFDHIRPDAKHNWLGQVDEENDWNEFLPVADKDTKQAKGLGQERAIFK
LYSLGVVTNRDEWVYSRAEDELADKVRYFIGRYNEIIKLPLGDLMSRNWE
GDIKMTRATIADAQSRKSYSLEKNSIVPSLYRPFDVLKMYFSKNLNEMQY
QMPSIFPKGVGENVVIALSGSPAAKPFQVLATDILPSLDLLEKTQCLPFY
RYTMNGERLNNITDYALKAFQTHYAISREDIFHYVYAVLHHPAYREKYAL
NLRQEFPRIPFYPEFGRWAAWGRELMALHIGFESVAPYPLKRTDEPPKND
TPEALALAKKARLKVQRDAAKQPTGAVELDGLTTLAGIPAAAWAYKLGNR
SALEWVLERHKETTPKDATIREKFNTYRFADHKERVIDLLARVTTVSVET
VRIVGEMPAETM
Ligand information
Ligand IDSAM
InChIInChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27-/m0/s1
InChIKeyMEFKEPWMEQBLKI-FCKMPRQPSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[S@@+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
OpenEye OEToolkits 1.5.0C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O
CACTVS 3.341C[S+](CC[CH](N)C([O-])=O)C[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23
OpenEye OEToolkits 1.5.0C[S@@+](CC[C@@H](C(=O)[O-])N)C[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)O
ACDLabs 10.04[O-]C(=O)C(N)CC[S+](C)CC3OC(n2cnc1c(ncnc12)N)C(O)C3O
FormulaC15 H22 N6 O5 S
NameS-ADENOSYLMETHIONINE
ChEMBLCHEMBL1235831
DrugBank
ZINC
PDB chain7lo5 Chain D Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7lo5 Coordination of phage genome degradation versus host genome protection by a bifunctional restriction-modification enzyme visualized by CryoEM.
Resolution2.86 Å
Binding residue
(original residue number in PDB)		Y286 L301 G302 F304 Y305 T306 A341 T342 G343 T346 F347 E372 L373 D406 P450 M492 F496
Binding residue
(residue number reindexed from 1)		Y286 L301 G302 F304 Y305 T306 A341 T342 G343 T346 F347 E372 L373 D406 P442 M484 F488
Annotation score5
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004519 endonuclease activity
GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0009307 DNA restriction-modification system
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7lo5, PDBe:7lo5, PDBj:7lo5
PDBsum7lo5
PubMed33826880
UniProtA0A345IJ72

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