Structure of PDB 4xl1 Chain D Binding Site BS06

Receptor Information
>4xl1 Chain D (length=117) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PDVDECALGANPCEHAGKCLNTLGSFECQCLQGYTGPRCEIDVNECISNP
CQNDATCLDQIGEFQCICMPGYEGVYCEINTDECASSPCLHNGRCVDKIN
EFLCQCPKGFSGHLCQS
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4xl1 Chain D Residue 607 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4xl1 Structural biology. Structural basis for Notch1 engagement of Delta-like 4.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D412 V413 E415 N431 T432 L433 G434 S435
Binding residue
(residue number reindexed from 1)		D2 V3 E5 N21 T22 L23 G24 S25
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:4xl1, PDBe:4xl1, PDBj:4xl1
PDBsum4xl1
PubMed25700513
UniProtQ07008|NOTC1_RAT Neurogenic locus notch homolog protein 1 (Gene Name=Notch1)

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