Structure of PDB 6vfu Chain C Binding Site BS06

Receptor Information
>6vfu Chain C (length=428) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASAFRVVSNSAPHL
VDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIKD
LNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPN
ELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGT
VGLSIKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNG
QVVYSFYGYVNDRTRELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDL
GPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSESAPPGYVIALV
RVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYNL
TIQARDGGVPMLQSAKSFTVLITDHHHH
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6vfu Chain C Residue 506 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6vfu Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered delta-Protocadherins.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		N211 N213 D243 D245 N249 D299
Binding residue
(residue number reindexed from 1)		N211 N213 D243 D245 N249 D299
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6vfu, PDBe:6vfu, PDBj:6vfu
PDBsum6vfu
PubMed32101743
UniProtQ8TAB3|PCD19_HUMAN Protocadherin-19 (Gene Name=PCDH19)

[Back to BioLiP]