Structure of PDB 6cnl Chain C Binding Site BS06

Receptor Information
>6cnl Chain C (length=189) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKATRHIFLIRASQYHVRTLTPLGREQAELTGLRLASLGLKFNKIVHSSM
TRAIETTDIISRHLPGVCKVSTDLLREGAPIEPDPPVSHWKPEAVQYYED
GARIEAAFRNYIHRADARQEEDSYEIFICHANVIRYIVCRALQFPPEGWL
RLSLNNGSITHLVIRPNGRVALRTLGDTGFMPPDKITRS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6cnl Chain C Residue 304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6cnl Functional role of PGAM5 multimeric assemblies and their polymerization into filaments.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		A96 R98 R214 A215 I264 R265 P266
Binding residue
(residue number reindexed from 1)		A3 R5 R114 A115 I164 R165 P166
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
External links
PDB RCSB:6cnl, PDBe:6cnl, PDBj:6cnl
PDBsum6cnl
PubMed30705304
UniProtQ96HS1|PGAM5_HUMAN Serine/threonine-protein phosphatase PGAM5, mitochondrial (Gene Name=PGAM5)

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