Structure of PDB 5n6n Chain C Binding Site BS06

Receptor Information
>5n6n Chain C (length=698) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPFSNAEVYYGNRTRTMSVFDNVSPFKKTGFGKLQQTRRGSEDDTYSSSQ
GNRRFFIEDVDKTLNELLAAEDTDKNYQITIEDTGPKVLKVGTANSYGYK
HINIRGTYMLSNLLQELTIAKSFGRHQIFLDEARINENPVNRLSRLINTQ
FWNSLTRRVDLNNVGEIAKDTKIDTPGAKNPRIYVPYDCPEQYEFYVQAS
QMHPSLKLEVEYLPKKITAEYVKSVNDTPGLLALAMEEHFNPSTGEKTLI
GYPYAVPGGRFNELYGWDSYMMALGLLEANKTDVARGMVEHFIFEINHYG
KILNANRSYYLCRSQPPFLTEMALVVFKKLGGRSNPDAVDLLKRAFQASI
KEYKTVWTASPRLDPETGLSRYHPNGLGIPPETESDHFDTVLLPFKQLYN
DGKIKEPKLDEFFLHDRGVRESGHDTTYRFEGVCAYLATIDLNSLLYKYE
IDIADFIKEFCDDKYEDPLDHSITTSAMWKEMAKIRQEKITKYMWDDESG
FFFDYNTKIKHRTSYESATTFWALWAGLATKEQAQKMVEKALPKLEMLGG
LAACTERSRGPISISRPIRQWDYPFGWAPHQILAWEGLRSYGYLTVTNRL
AYRWLFMMTKAFVDYNGIVVEKYDVTRGTDPHRVEAEYGNQGADFKGAAT
EGFGWVNASYILGLKYMNSHARRALGACIPPISFFSSLRPQERNLYGL
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5n6n Chain C Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5n6n Molecular basis of the 14-3-3 protein-dependent activation of yeast neutral trehalase Nth1.
Resolution2.29 Å
Binding residue
(original residue number in PDB)		D114 D116 N118 Q120 D125
Binding residue
(residue number reindexed from 1)		D72 D74 N76 Q78 D83
Annotation score1
Enzymatic activity
Enzyme Commision number 3.2.1.28: alpha,alpha-trehalase.
Gene Ontology
Molecular Function
GO:0004555 alpha,alpha-trehalase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015927 trehalase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005991 trehalose metabolic process
GO:0005993 trehalose catabolic process
GO:0071465 cellular response to desiccation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5n6n, PDBe:5n6n, PDBj:5n6n
PDBsum5n6n
PubMed29087344
UniProtP32356|TREA_YEAST Cytosolic neutral trehalase (Gene Name=NTH1)

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