Structure of PDB 6t0v Chain B Binding Site BS06

Receptor Information
>6t0v Chain B (length=745) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPMLIFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVIRTHDYS
SRGIWKTNSETGAQQLNPIDGPLPEDNEPSGYAQTDCVLELIEGLDRSHP
GLFETACQETIDAIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RKNGYKLNESGRLIDFLKDVLLSFENDSMEVTTHFQKKKRIRDNHSKKMI
TQRTIGKKRVKLTKKNYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRG
FVYFVELLARNICERLEQSGLPVGGNEKKAKLANVIKKMMAKSTDEELSY
TITGDNTKWNENQNPRIFLAMVLRITAGQPEWFRDLLAVAPIMFSNKVAR
LGRGYMFESKSMHLRTQISAENLSDINLRYFNEDTKKKIEKIRHLMVEGT
ASLSPGMMMGMFNMLSTVLGVSVLNLGQREILKRTYWWDGLQSSDDFALI
INGHFKEDIQQGVNHFYRTCKLVGINMSQKKSYINKTGTFEFTSFFYRYG
FVANFSMELPSFGVAGNNESADMSIGTTVIKTNMINNDLGPATAQMAIQL
FIKDYRYTYRCHRGDTNLETRRTKSIKRLWTETISKAGLLVADGGPNPYN
LRNLHIPEVCLKWSLMDPDYRGRLCNPNNPFVHHMEVESTKSLEYDAVAT
THSWTPKRNRSILNTNQRGILEDERIYQKCCQVFEKFFPSSTYRRPIGMA
SMLDAMLSRARIDARIDLESGRISSQDFSEITNTCKAIEALKRQG
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6t0v Chain B Residue 804 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6t0v A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
Resolution3.02 Å
Binding residue
(original residue number in PDB)		D305 D445 D446
Binding residue
(residue number reindexed from 1)		D305 D445 D446
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t0v, PDBe:6t0v, PDBj:6t0v
PDBsum6t0v
PubMed32304664
UniProtH6QM91

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