Structure of PDB 6evk Chain B Binding Site BS06

Receptor Information
>6evk Chain B (length=748) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPMLIFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVIRTHDYS
SRGIWKTNSETGAQQLNPIDGPLPEDNEPSGYAQTDCVLELIEGLDRSHP
GLFETACQETIDAIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RKNGYKLNESGRLIDFLKDVLLSFENDSMEVTTHFQKKKRIRDNMITQRT
IGKKRVKLTKKNYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYF
VELLARNICERLEQSGLPVGGNEKKAKLANVIKKMMAKSTDEELSYTITG
DNTKWNENQNPRIFLAMVLRITAGQPEWFRDLLAVAPIMFSNKVARLGRG
YMFESKSMHLRTQISAENLSDINLRYFNEDTKKKIEKIRHLMVEGTASLS
PGMMMGMFNMLSTVLGVSVLNLGQREILKRTYWWDGLQSSDDFALIINGH
FKEDIQQGVNHFYRTCKLVGINMSQKKSYINKTGTFEFTSFFYRYGFVAN
FSMELPSFGVAGNNESADMSIGTTVIKTNMINNDLGPATAQMAIQLFIKD
YRYTYRCHRGDTNLETRRTKSIKRLWTETISKAGLLVADGGPNPYNLRNL
HIPEVCLKWSLMDPDYRGRLCNPNNPFVHHMEVESTNLAVVMPGPAKSLE
YDAVATTHSWTPKRNRSILNTNQRGILEDERIYQKCCQVFEKFFPSSTYR
RPIGMASMLDAMLSRARIDARIDLESGRISSQDFSEITNTCKAIEALK
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain6evk Chain C Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6evk Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		N16 R498
Binding residue
(residue number reindexed from 1)		N16 R494
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6evk, PDBe:6evk, PDBj:6evk
PDBsum6evk
PubMed29202182
UniProtH6QM91

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