Structure of PDB 4gn9 Chain B Binding Site BS06

Receptor Information
>4gn9 Chain B (length=297) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SIKVECVLRENYRCGESPVWEEASQSLLFVDIPSKIICRWDTVSNQVQRV
AVDAPVSSVALRQLGGYVATIGTKFCALNWENQSVFVLAMVDEDKKNNRF
NDGKVDPAGRYFAGTMAEETAPAVLERHQGSLYSLFPDHSVKKYFDQVDI
SNGLDWSLDHKIFYYIDSLSYTVDAFDYDLQTGQISNRRIVYKMEKDEQI
PDGMCIDAEGKLWVACYNGGRVIRLDPETGKRLQTVKLPVDKTTSCCFGG
KDYSEMYVTCARDGLNAEGLLRQPDAGNIFKITGLGVKGIAPYSYAG
Ligand information
Ligand IDBGC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-VFUOTHLCSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O
CACTVS 3.370OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 1.7.6C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
ACDLabs 12.01OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namebeta-D-glucopyranose;
beta-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL1614854
DrugBankDB02379
ZINCZINC000003833800
PDB chain4gn9 Chain B Residue 310 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4gn9 Structural basis of the gamma-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase
Resolution2.0 Å
Binding residue
(original residue number in PDB)		R191 P229
Binding residue
(residue number reindexed from 1)		R189 P227
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.1.17: gluconolactonase.
Gene Ontology
Molecular Function
GO:0004341 gluconolactonase activity
GO:0005509 calcium ion binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0030234 enzyme regulator activity
GO:0046872 metal ion binding
Biological Process
GO:0001822 kidney development
GO:0001889 liver development
GO:0006874 intracellular calcium ion homeostasis
GO:0007283 spermatogenesis
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010907 positive regulation of glucose metabolic process
GO:0019853 L-ascorbic acid biosynthetic process
GO:0032781 positive regulation of ATP-dependent activity
GO:0043066 negative regulation of apoptotic process
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050848 regulation of calcium-mediated signaling
GO:0097421 liver regeneration
GO:1901318 negative regulation of flagellated sperm motility
GO:1902679 negative regulation of RNA biosynthetic process
GO:1903011 negative regulation of bone development
GO:1903052 positive regulation of proteolysis involved in protein catabolic process
GO:1903625 negative regulation of DNA catabolic process
GO:2000279 negative regulation of DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4gn9, PDBe:4gn9, PDBj:4gn9
PDBsum4gn9
PubMed23349732
UniProtQ64374|RGN_MOUSE Regucalcin (Gene Name=Rgn)

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