Structure of PDB 4v67 Chain AX Binding Site BS06

Receptor Information
>4v67 Chain AX (length=362) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NASRNAWKASGGIFDIPQKETRLKELERRLEDPSLWNDPEAARKVSQEAA
RLRRTVDTFRSLESDLQGLLELMEELPAEEREALKPELEEAAKKLDELYH
QTLLNFPHAEKNAILTIQPGAGGTEACDWAEMLLRMYTRFAERQGFQVEV
VDLTPGPEAGIDYAQILVKGENAYGLLSPEAGVHRLVRPSPFDASGRRHT
SFAGVEVIPEVDEEVEVVLKPEELRIDVMRASGPGGQGVNTTDSAVRVVH
LPTGITVTCQTTRSQIKNKELALKILKARLYELERKKREEELKALRGEVR
PIEWGSQIRSYVLDKNYVKDHRTGLMRHDPENVLDGDLMDLIWAGLEWKA
GRRQGTEEVEAE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4v67 Chain AX Residue 408 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4v67 Crystal structure of a translation termination complex formed with release factor RF2.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		K236 E238
Binding residue
(residue number reindexed from 1)		K220 E222
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003747 translation release factor activity
GO:0016149 translation release factor activity, codon specific
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
GO:0006415 translational termination
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4v67, PDBe:4v67, PDBj:4v67
PDBsum4v67
PubMed19064930
UniProtQ5SM01|RF2_THET8 Peptide chain release factor RF2 (Gene Name=prfB)

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