Structure of PDB 8xme Chain A Binding Site BS06

Receptor Information
>8xme Chain A (length=1176) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQVPVGTLTSIGFSISNNNDRDKMSVLEVEAPNQVTDSRLGLPNPDSVCR
TCGSKDRKVCEGHFGVINFAYSIINPYFLKEVAALLNKICPGCKYICRYC
TLNTGYPLMKFRVTTKEVFRRSGIVVEVNEESLMKLKKRGVLTLPPDYWS
FLPQDSNIDESCLKPTRRIITHAQVYALLLGIDQRLIKKDIPMFNSLGLT
SFPVTPNGYRVTEIVHQFNGARLIFDERTRIYKKLVGFEGNTLELSSRVM
ECMQYSRLFSEKLCGLRFMKDVLLGKRSDHTFRTVVVGDPSLKLNEIGIP
ESIAKRLQVSEHLIFRSLMDGDTVLMNRPPSIHQHSLIAMTVRILPTTSV
VSLNPICCLPFRGDFDGDCLHGYVPQSIQAKVELDELVALDKQLINRQNG
RNLLSLGQDSLTAAYLVNVEKNCYLNRAQMQQLQMYCPFQLPPPAIIKAS
PSSTEPQWTGMQLFGMLFPPGFDYTYPLNNVVVSNGELLSFSEGSAWLRD
GEGNFIERLLKHDKGKVLDIIYSAQEMLSQWLLMRGLSVSLADLYLSSDL
QSRKNLTEEISYGLREAEQVCNKQQLMVESWRDFLAVNGEDKEEDSVSDL
ARFCYERQKSATLSELAVSAFKDAYRDVQALAYRYGDQSNSFLIMSKAGS
KGNIGKLVQHSMCIGLQNSAVSLSFGFPRELTCAAWNDPNSPLRGAKGKT
TTESYVPYGVIENSFLTGLNPLESFVHSVTSRDSSFSGNADLPGTLSRRL
MFFMRDIYAAYDGTVRNSFGNQLVQFTYETDGPVEDITGEALGSLSACAL
SEAAYSALDQPISLLETSPLLNLKNVLECGSKKGQREQTMSLYLSEYLSK
KKHGFEYGSLEIKNHLEKLSFSEIVSTSMIIFSPVPLSPWVCHFHISEKV
LKRKQLSAESVVSSLNEQYKSRNRELKLDIVDLDIQNTNHCSSDDQAMKD
DNVCITVTVVEASKHSVLELDAIRLVLIPFLLDSPVKGDQGIKKVNILWT
DRPKAPKRNGNHLAGELYLKVTMYGDRGKRNCWTALLETCLPIMDMIDWG
RSHPDNIRQCCSVYGIDAGRSIFVANLESAVSDTGKEILREHLLLVADSL
SVTGEFVALNAKGWSKQRQVESTPAPFTQACFSSPSQCFLKAAKEGVRDD
LQGSIDALAWGKVPGFGTGDQFEIII
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8xme Chain A Residue 1504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8xme Transcription of the Plant RNA polymerase IV is prone to backtracking
Resolution3.1 Å
Binding residue
(original residue number in PDB)		C97 C100 C118
Binding residue
(residue number reindexed from 1)		C90 C93 C97
Annotation score1
Gene Ontology
Molecular Function
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0010495 siRNA-mediated long-distance post-transcriptional gene silencing
GO:0030422 siRNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing
Cellular Component
GO:0000418 RNA polymerase IV complex
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xme, PDBe:8xme, PDBj:8xme
PDBsum8xme
PubMed
UniProtQ9LQ02|NRPD1_ARATH DNA-directed RNA polymerase IV subunit 1 (Gene Name=NRPD1)

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