Structure of PDB 8sjy Chain A Binding Site BS06

Receptor Information
>8sjy Chain A (length=220) Species: 9940 (Ovis aries) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SASFWRAIFAEFFATLFYVFFGLGASLRWAPGPLHVLQVALAFGLALATL
VQAVGHISGAHVNPAVTFAFLVGSQMSLLRAICYVVAQLLGAVAGAAVLY
SVTPPAVRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNG
RLGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYW
VGPVIGAGLGSLLYDFLLFP
Ligand information
Ligand IDCLR
InChIInChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKeyHVYWMOMLDIMFJA-DPAQBDIFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
CACTVS 3.341CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
ACDLabs 10.04OC4CCC3(C(=CCC2C1C(C(C(C)CCCC(C)C)CC1)(C)CCC23)C4)C
OpenEye OEToolkits 1.5.0CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
CACTVS 3.341CC(C)CCC[CH](C)[CH]1CC[CH]2[CH]3CC=C4C[CH](O)CC[C]4(C)[CH]3CC[C]12C
FormulaC27 H46 O
NameCHOLESTEROL
ChEMBLCHEMBL112570
DrugBankDB04540
ZINCZINC000003875383
PDB chain8sjy Chain A Residue 309 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8sjy Structure of aquaporin-0 arrays in sphingomyelin/cholesterol membranes and implications for lipid rafts
Resolution2.35 Å
Binding residue
(original residue number in PDB)		W10 V91
Binding residue
(residue number reindexed from 1)		W5 V86
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005212 structural constituent of eye lens
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0015250 water channel activity
GO:0015267 channel activity
Biological Process
GO:0002088 lens development in camera-type eye
GO:0006833 water transport
GO:0007601 visual perception
GO:0045785 positive regulation of cell adhesion
GO:0051289 protein homotetramerization
GO:0055085 transmembrane transport
GO:1990349 gap junction-mediated intercellular transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005921 gap junction
GO:0016020 membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sjy, PDBe:8sjy, PDBj:8sjy
PDBsum8sjy
PubMed39222068
UniProtQ6J8I9|MIP_SHEEP Lens fiber major intrinsic protein (Gene Name=MIP)

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