Structure of PDB 8jxb Chain A Binding Site BS06

Receptor Information
>8jxb Chain A (length=244) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DTGTRCNQLQFTCLNGHCINQDWKCDNDNDCGDGSDELPTVCAFHTCRST
AFTCGNGRCVPYHYRCDYYNDCGDNSDEAGCLFRNCNSTTEFTCSNGRCI
PLSYVCNGINNCHDNDTSDEKNCPPHTCPPDFTKCQTTNICVPRAFLCDG
DNDCGDGSDENPIYCASHTCRSNEFQCLSPQRCIPSYWFCDGEADCADGS
DEPDTCGHSVNTCRASQFQCDNGRCISGNWVCDGDNDCGDMSDE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8jxb Chain A Residue 4709 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jxb Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		W2925 D2928 D2930 D2932 D2938 E2939
Binding residue
(residue number reindexed from 1)		W230 D233 D235 D237 D243 E244
Annotation score4
External links
PDB RCSB:8jxb, PDBe:8jxb, PDBj:8jxb
PDBsum8jxb
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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