Structure of PDB 8cls Chain A Binding Site BS06

Receptor Information
>8cls Chain A (length=837) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTMRLSQNVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLNR
SFPKLTEVTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNF
DLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTE
NGKEKQLHNNRRLCWNSKLCQTKCPEKCRNNCIDEHTCCSQDCLGGCVID
KNGNESCISCRNVSFNNICMDSCPKGYYQFDSRCVTANECITLTKFETNS
VYSGIPYNGQCITHCPTGYQKSENKRMCEPCPGGKCDKECSSGLIDSLER
AREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHL
TYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQTVFIR
KGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTA
VLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYH
MIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMA
ISSELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYG
VLTRYFIKAKLINRPTRNNNRDYCTEPLGMEFENALQNFIFVPNKDDENT
YKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEI
PSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESP
VRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIK
LNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAK
Ligand information
>8cls Chain H (length=26) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SLRACGPALMDMLRVACPNGFNSMFA
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cls Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		S341 R345 N346 Y392
Binding residue
(residue number reindexed from 1)		S14 R18 N19 Y65
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:8cls, PDBe:8cls, PDBj:8cls
PDBsum8cls
PubMed37805602
UniProtP09208|INSR_DROME Insulin-like receptor (Gene Name=InR)

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