Structure of PDB 7y80 Chain A Binding Site BS06

Receptor Information

>7y80 Chain A (length=1218) Species: 237368 (Candidatus Scalindua brodae)

MNITVELTFFEPYRLVEWFDWDARKKSHSAMRGQAFAQWTWKGKGRTAGK
SFITGTLVRSAVIKAVEELLSLNNGKWEGVPCCNGSFQTDESKGKKPSFL
RKRHTLQWQANNKNICDKEEACPFCILLGRFDNAGKVHERNKDYDIHFSN
FDLDHDLRLVDIASGRILNRVDFDTGKAKDYFRTWEADYETYGTYTGRIT
LRNEHAKKLLLASLGFVDKLCGALCRIEVIDHNDELRKQAEVIVEAFKQN
DKLEKIRILADAIRTLRLHGEGVIEKDELPDGKEERDKGHHLWDIKVQGT
ALRTKLKELWQSNKDIGWRKFTEMLGSNLYLIYKKETTEYYSSDLFIPVT
PPEGIETKEWIIVGRLKAATPFYFGVQQPSDSIPGKEEHTSFNILLDKEN
RYRIPRSALRGALRRDLRTAFGSGCNVSLGGQILCNCKVCIEMRRITLKD
SVSDFSEPPEIRYRIAKNPGTATVEDGSLFDIEVGPEGLTFPFVLRYRGH
KFPEQLSSVIRYWEENDGKNGMAWLGGLDSTGKGRFALKDIKIFEWDLNQ
KINEYIKERGMRGKEKELLEMGESSLPDGLIPYKFFEERECLFPYKENLK
PQWSEVQYTIEVGSPLLTADTISALTEPGNRDAIAYKKRVYNDGNNAIEP
EPRFAVKSETHRGIFRTAVGRRTGDLGKEDHEDCTCDMCIIFGNEHESSK
IRFEDLELINGNEFEKLEKHIDHVAIDRFTGGALDKAKFDTYPLAGSPKK
PLKLKGRFWIKKGFSGDHKLLITTALSDIRDGLYPLGSKGGVGYGWVAGI
SIDDNVINNDYVHPGHQSPKQDHKNKNIYYPHYFLDSGSKVYREKDIITH
EEFTEELLSGKINCKLETLTPLIIPDTSDENGLKLQGNKPGHKNYKFFNI
NGELMIPGSELRGMLRTHFEALTKSCFAIFGEDSTLSASKTLGGKLDKAL
HPCTGLSDGLCPGCHLFGTTDYKGRVKFGFAKYENGPEWLITRGNNPERS
LTLGVLESPRPAFSIPDDESEIPGRKFYLHHNGWRIIRQKQLEIRETVQP
ERNVTTEVMDKGNVFSFDVRFENLREWELGLLLQSLDPGKNIAHKLGKGK
PYGFGSVKIKIDSLHTFKIKRVPQSDIREYINKGYQKLIEWSGLPQWHVI
PHIDKLYKLLWVPFLSKLEPDVRYPVLNEESKGYIEGSDYTYKKLGDKDN
LPYKTRVKGLTTPWSPWN

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7y80 Chain A Residue 1805

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7y80 Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase
• Resolution: 2.71 Å
• Binding residue (original residue number in PDB): G134 D137
• Binding residue (residue number reindexed from 1): G129 D132
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0051607 defense response to virus

External links

• PDB: RCSB:7y80, PDBe:7y80, PDBj:7y80
• PDBsum: 7y80
• PubMed: 36477448
• UniProt: A0A0B0EGF3