Structure of PDB 7sz8 Chain A Binding Site BS06

Receptor Information
>7sz8 Chain A (length=420) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDT
PTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSV
SITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQ
LTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTA
HVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENAR
ITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKS
DTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGP
NGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDR
GSPTPLSASVEIQVTILDIN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7sz8 Chain A Residue 807 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7sz8 Crystal structure of human CELSR1 EC4-7
Resolution2.337 Å
Binding residue
(original residue number in PDB)		E565 D616 E618 D652
Binding residue
(residue number reindexed from 1)		E227 D278 E280 D314
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609 cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7sz8, PDBe:7sz8, PDBj:7sz8
PDBsum7sz8
PubMed
UniProtQ9NYQ6|CELR1_HUMAN Cadherin EGF LAG seven-pass G-type receptor 1 (Gene Name=CELSR1)

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