Structure of PDB 7ol0 Chain A Binding Site BS06

Receptor Information
>7ol0 Chain A (length=1407) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMD
PRQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRC
VCFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGGC
GRYQPRIRRSGLELYAEWKHVQEKKILLSPERVHEIFKRISDEECFVLGM
EPRYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINN
QLRRNEQNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKS
LKQRLKGKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANM
TFAEIVTPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDL
HLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSV
TTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIV
QDTLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTG
KQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMG
ILCKKSLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIG
IGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFE
NQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVV
GQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFF
HAMGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQ
LRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDL
VKDVLSNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIW
NAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENAT
LLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVG
ALAAQSLGEPATQMKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARD
AERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYISP
WLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNKLVLRIRIMNK
MDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEF
KALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKAL
ERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLM
KCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAE
KCKYGME
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7ol0 Chain A Residue 2003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7ol0 Allosteric transcription stimulation by RNA polymerase II super elongation complex.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		C111 C154
Binding residue
(residue number reindexed from 1)		C102 C145
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ol0, PDBe:7ol0, PDBj:7ol0
PDBsum7ol0
PubMed34265249
UniProtA0A7M4DUC2

[Back to BioLiP]