Structure of PDB 7kta Chain A Binding Site BS06

Receptor Information

>7kta Chain A (length=328) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

WMPAYACQRPTPLTHHNTGLSEALEILAEAAGFEGSEGRLLTFCRAASVL
KALPSPVTTLSQLQGLPHFGEHSSRVVQELLEHGVCEEVERVRRSERYQT
MKLFTQIFGVGVKTADRWYREGLRTLDDLREQPQKLTQQQKAGLQHHQDL
STPVLRSDVDALQQVVEEAVGQALPGATVTLTGGFRRGKLQGHDVDFLIT
HPKEGQEAGLLPRVMCRLQDQGLILYHQHAFERSFCIFRLPQPGSWKAVR
VDLVVAPVSQFPFALLGWTGSKLFQRELRRFSRKEKGLWLNSHGLFDPEQ
KTFFQAASEEDIFRHLGLEYLPPEQRNA

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

7kta Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7kta Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide.
Resolution	1.844 Å
Binding residue (original residue number in PDB)	D330 D332 D418
Binding residue (residue number reindexed from 1)	D194 D196 D252
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0016779	nucleotidyltransferase activity
GO:0034061	DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:7kta, PDBe:7kta, PDBj:7kta
PDBsum	7kta
PubMed	33824325
UniProt	Q9NP87\|DPOLM_HUMAN DNA-directed DNA/RNA polymerase mu (Gene Name=POLM)

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