Structure of PDB 6jlh Chain A Binding Site BS06

Receptor Information
>6jlh Chain A (length=261) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLDAAGFLQIWQHFDADDNGYIEGKELDDFFRHMLKKLQPKDKITDERVQ
QIKKSFMSAYDATFDGRLQIEELANMILPQEENFLLIFRREAPLDNSVEF
MKIWRKYDADSSGYISAAELKNFLKDLFLQHKKKIPPNKLDEYTDAMMKI
FDKNKDGRLDLNDLARILALQENFLLQFKMDASSQVERKRDFEKIFAHYD
VSRTGALEGPEVDGFVKDMMELVRPSISGGDLDKFRECLLTHCDMNKDGK
IQKSELALCLG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6jlh Chain A Residue 305 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6jlh Structural and mechanistic insights into secretagogin-mediated exocytosis.
Resolution2.37 Å
Binding residue
(original residue number in PDB)		D158 N160 D162 R164
Binding residue
(residue number reindexed from 1)		D152 N154 D156 R158
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0007420 brain development
GO:0021522 spinal cord motor neuron differentiation
GO:0099509 regulation of presynaptic cytosolic calcium ion concentration
GO:1900271 regulation of long-term synaptic potentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030425 dendrite
GO:0043195 terminal bouton
GO:0045202 synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jlh, PDBe:6jlh, PDBj:6jlh
PDBsum6jlh
PubMed32156735
UniProtQ5XJX1|SEGN_DANRE Secretagogin (Gene Name=scgn)

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