Structure of PDB 5d7w Chain A Binding Site BS06

Receptor Information
>5d7w Chain A (length=469) Species: 615 (Serratia marcescens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATGYDAVDDLLHYHERGNGIQINGKDSFSNEQAGLFITRENQTWNGYKVF
GQPVKLTFSFPDYKFSSTNVAGDTGLSKFSAEQQQQAKLSLQSWADVANI
TFTEVAAGQKANITFGNYSQDRPGHYDYGTQAYAFLPNTIWQGQDLGGQT
WYNVNQSNVKHPATEDYGRQTFTHEIGHALGLSHPGDYNAGEGNPTYNDV
TYAEDTRQFSLMSYWSETNTGGDNGGHYAAAPLLDDIAAIQHLYGANLST
RTGDTVYGFNSNTGRDFLSTTSNSQKVIFAAWDAGGNDTFDFSGYTANQR
INLNEKSFSDVGGLKGNVSIAAGVTIENAIGGSGNDVIVGNAANNVLKGG
AGNDVLFGGGGADELWGGAGKDIFVFSAASDSAPGASDWIRDFQKGIDKI
DLSFFNKEANSSDFIHFVDHFSGTAGEALLSYNASSNVTDLSVNIGGHQA
PDFLVKIVGQVDVATDFIV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5d7w Chain A Residue 506 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5d7w Structure of a thermostable serralysin from Serratia sp. FS14 at 1.1 angstrom resolution.
Resolution1.1 Å
Binding residue
(original residue number in PDB)		G352 A353 G354 D356 G369 G370 A371 D374
Binding residue
(residue number reindexed from 1)		G350 A351 G352 D354 G367 G368 A369 D372
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.40: serralysin.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0001907 symbiont-mediated killing of host cell
GO:0006508 proteolysis
GO:0035821 modulation of process of another organism
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5d7w, PDBe:5d7w, PDBj:5d7w
PDBsum5d7w
PubMed26750478
UniProtP23694|PRZN_SERMA Serralysin

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