Structure of PDB 4m8l Chain A Binding Site BS06

Receptor Information

>4m8l Chain A (length=220) Species: 263 (Francisella tularensis)

KKNNQDELKKLAATEAAKSITTEITLGVGTGSTVGFLIEELVNYRDKIKT
VVSSSEDSTRKLKALGFDVVDLNYAGEIDLYIDGADECNNHKELIKGGGA
ALTREKICVAAAKKFICIIDESKKVNTLGNFPLPIEVIPMARSYIARQIV
KLGGQPVYREQTITDNGNVILDVYNLKIDNPLKLETELNQITGVVTNGIF
ALKPADTVIMATKDSNIVVL

Ligand information

• Ligand ID: ARF
• InChI: InChI=1S/CH3NO/c2-1-3/h1H,(H2,2,3)
• InChIKey: ZHNUHDYFZUAESO-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C(=O)N
  CACTVS 3.341: NC=O
  ACDLabs 10.04: O=CN
• Formula: C H3 N O
• Name: FORMAMIDE
• ChEMBL: CHEMBL266160
• PDB chain: 4m8l Chain A Residue 313

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4m8l crystal structure of RpiA-R5P complex
• Resolution: 2.37 Å
• Binding residue (original residue number in PDB): K67 D72 V73
• Binding residue (residue number reindexed from 1): K63 D68 V69
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 5.3.1.6: ribose-5-phosphate isomerase.

Gene Ontology

Molecular Function

• GO:0004751 ribose-5-phosphate isomerase activity
• GO:0016853 isomerase activity

Biological Process

• GO:0006014 D-ribose metabolic process
• GO:0006098 pentose-phosphate shunt
• GO:0009052 pentose-phosphate shunt, non-oxidative branch
• GO:0044281 small molecule metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:4m8l, PDBe:4m8l, PDBj:4m8l
• PDBsum: 4m8l
• UniProt: A4IYN5|RPIA_FRATW Ribose-5-phosphate isomerase A (Gene Name=rpiA)