Structure of PDB 4kpy Chain A Binding Site BS06

Receptor Information
>4kpy Chain A (length=676) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNHLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVA
RRAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDP
KDPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGG
AVLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRR
TWELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKPI
PHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIGRRLGLGTPEAV
RAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPE
FLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVL
TPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKAG
LQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQ
AGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALE
ALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRD
FRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLA
DRLVKEVGRLGIRHLKEVDREKLFFV
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4kpy Chain A Residue 703 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4kpy Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Resolution2.406 Å
Binding residue
(original residue number in PDB)		D478 D546
Binding residue
(residue number reindexed from 1)		D469 D537
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:4kpy, PDBe:4kpy, PDBj:4kpy
PDBsum4kpy
PubMed24374628
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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