Structure of PDB 4gfh Chain A Binding Site BS06

Receptor Information
>4gfh Chain A (length=1102) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SASDKYQKISQLEHILKRPDTYIGSVETQEQLQWIYDEETDCMIEKNVTI
VPGLFKIFDEILVNAADNKVRDPSMKRIDVNIHAEEHTIEVKNDGKGIPI
EIHNKENIYIPEMIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEF
ILETADLNVGQKYVQKWENNMSICHPPKITSYKKGPSYTKVTFKPDLTRF
GMKELDNDILGVMRRRVYDINGSVRDINVYLNGKSLKIRNFKNYVELYLK
SLIPTILYERINNRWEVAFAVSDISFQQISFVNSIATTMGGTHVNYITDQ
IVKKISEILKKKKKKSVKSFQIKNNMFIFINCLIENPAFTSQTKEQLTTR
VKDFGSRCEIPLEYINKIMKTDLATRMFEIADANESRITNYPKLEDANKA
GTKEGYKCTLVLTEGDSALSLAVAGLAVVGRDYYGCYPLRGKMLNVREAS
ADQILKNAEIQAIKKIMGLQHRKKYEDTKSLRYGHLMIMTDQDHDGSHIK
GLIINFLESSFPGLLDIQGFLLEFITPIIKVSITKPTKNTIAFYNMPDYE
KWREEESHKFTWKQKYYTSLAQEVREYFSNLDRHLKIFHSLQGNDKDYID
LAFSKKKADDRKEWLRQYEPGTVLDPTLKEIPISDFINKELILFSLADNI
RSIPNVLDGFKPGQRKVLYGCFKKNLKSELKVAQLAPYVSECTAYHHGEQ
SLAQTIIGLAQNFVGSNNIYLLLPNGAFGTRATGGKDAAAARYIYTELNK
LTRKIFHPADDPLYKYIQEDEKTVEPEWYLPILPMILVNGAEGIGTGWST
YIPPFNPLEIIKNIRHLMNDEELEQMHPWFRGWTGTIEEIEPLRYRMYGR
IEQIGDNVLEITELPARTWTSTIKEYLLLGLSGNDKIKPWIKDMEEQHDD
NIKFIITLSPEEMAKTRKIGFYERFKLISPISLMNMVAFDPHGKIKKYNS
VNEILSEFYYVRLEYYQKRKDHMSERLQWEVEKYSFQVKFIKMIIEKELT
VTNKPRNAIIQELENLGFPRFNKEGKPYYGSEELYGTYEYLLGMRIWSLT
KERYQKLLKQKQEKETELENLLKLSAKDIWNTDLKAFEVGYQEFLQRDAE
AR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4gfh Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity.
Resolution4.408 Å
Binding residue
(original residue number in PDB)		K428 D451 R475
Binding residue
(residue number reindexed from 1)		K393 D416 R440
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4gfh, PDBe:4gfh, PDBj:4gfh
PDBsum4gfh
PubMed23022727
UniProtP06786|TOP2_YEAST DNA topoisomerase 2 (Gene Name=TOP2)

[Back to BioLiP]