Structure of PDB 3hx0 Chain A Binding Site BS06

Receptor Information

>3hx0 Chain A (length=330) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SQKATNHNLHITEKLEVLAKAYSVQGDKWRAAGYAKAINALKSFHKPVTS
YQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAG
TKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEI
EQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFS
RLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVP
YSEFACALLYFTGSAAFNASMRALAKTKGMSLSEHALSTAVVRNTHGAKV
GPGRVLPTPTEKDVFRLLGLPYREPAERDW

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

3hx0 Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3hx0 Scrunching During DNA Repair Synthesis
Resolution	3.0 Å
Binding residue (original residue number in PDB)	D427 D429
Binding residue (residue number reindexed from 1)	D182 D184
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	D427 D429 D490
Catalytic site (residue number reindexed from 1)	D182 D184 D245
Enzyme Commision number	2.7.7.7: DNA-directed DNA polymerase. 4.2.99.-

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0016779	nucleotidyltransferase activity
GO:0034061	DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

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Molecular Function

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Biological Process

External links

PDB	RCSB:3hx0, PDBe:3hx0, PDBj:3hx0
PDBsum	3hx0
PubMed
UniProt	Q9UGP5\|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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