Structure of PDB 3f2c Chain A Binding Site BS06

Receptor Information
>3f2c Chain A (length=993) Species: 1462 (Geobacillus kaustophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VRRLETIVEEERRVVVQGYVFDAEVSELKSGRTLLTMKITDYTNSILVKM
FSRDKEDAELMSGVKKGMWVKVRGSVQNDTFVRDLVIIANDLNEIAANER
QDTAPEGEKRVELHLHTPMSQMDAVTSVTKLIEQAKKWGHPAIAVTDHAV
VQSFPEAYSAAKKHGMKVIYGLEANIVDDPFHVTLLAQNETGLKNLFKLV
SLSHIQYFHRVPRIPRSVLVKHRDGLLVGSGCDKGELFDNVEDIARFYDF
LEVHPPDVYKPLVKDEEMIKNIIRSIVALGEKLDIPVVATGNVHYLNPED
KIYRKILIHSQGGANPLNRHELPDVYFRTTNEMLDCFSFLGPEKAKEIVV
DNTQKIASLIGDVKPIKDELYTPRIEGADEEIREMSYRRAKEIYGDPLPK
LVEERLEKELKSIIGHGFAVIYLISHKLVKKSLDDGYLVGSRGSVGSSFV
ATMTEITEVNPLPPHYVCPNCKHSEFFNDGSVGSGFDLPDKNCPRCGTKY
KKDGHDIPFETFLGFKGDKVPDIDLNFSGEYQPRAHNYTKVLFGEDNVYR
AGTIGTVADKTAYGFVKAYASDHNLELRGAEIDRLAAGCTGVKRTTGQHP
GGIIVVPDYMEIYDFTPIQYPADDTSSEWRTTHFDFHSIHDNLLKLDILG
HDDPTVIRMLQDLSGIDPKTIPTDDPDVMGIFSSTEPLGVTPEQIMCNVG
TIGIPEFGTRFVRQMLEETRPKTFSELVQISGLSHGTDVWLGNAQELIQN
GTCTLSEVIGCRDDIMVYLIYRGLEPSLAFKIMESVRKGKGLTPEFEAEM
RKHDVPEWYIDSCKKIKYMFPKAHAAAYVLMAVRIAYFKVHHPLLYYASY
FTVRAEDFDLDAMIKGSAAIRKRIEEINAKGIQATAKEKSLLTVLEVALE
MCERGFSFKNIDLYRSQATEFVIDGNSLIPPFNAIPGLGTNVAQAIVRAR
EEGEFLSKEDLQQRGKLSKTLLEYLESRGCLDSLPDHNQLSLF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3f2c Chain A Residue 4 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3f2c Structure of PolC reveals unique DNA binding and fidelity determinants.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		C919 C922 C944 C947
Binding residue
(residue number reindexed from 1)		C468 C471 C493 C496
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:3f2c, PDBe:3f2c, PDBj:3f2c
PDBsum3f2c
PubMed19106298
UniProtQ5L0J3

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