Structure of PDB 2xzl Chain A Binding Site BS06

Receptor Information
>2xzl Chain A (length=756) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NSCAYCGIDSAKCVIKCNSCKKWFCNTKNGTSSSHIVNHLVLSHHNVVSL
HPDSDLGDTVLECYNCGRKNVFLLGFVSVVLLCRIPCAQTKWDTDQWQPL
IEDRQLLSWVAEQPTEEEKLKARLITPSQISKLEAKWRSNKDATIPPLLL
RYQDAYEYQRSYGPLIKLEADYDKQLKESQEHISVSWSLALNNRHLASFT
KVAIGDEMILWYSGMQHPDWEGRGYIVRLPNDTFTLELKPSKTPPPTHLT
TGFTAEFIWKGTSYDRMQDALKKFAIDKKSISGYLYYKILGHQVVDISFD
VPLPKEFSIPNFAQLNSSQSNAVSHVLQRPLSLIQGPPGTGKTVTSATIV
YHLSKIHKDRILVCAPSNVAVDHLAAKLRDLGLKVVRLTAKSREDVESSV
SNLALHNLVGRGAKGELKNLLKLKDEVGELSASDTKRFVKLVRKTEAEIL
NKADVVCCTCVGAGDKRLDTKFRTVLIDESTQASEPECLIPIVKGAKQVI
LVGDHQQLGPVILERKAADAGLKQSLFERLISLGHVPIRLEVQYRMNPYL
SEFPSNMFYEGSLQNGVTIEQRTVPNSKFPWPIRGIPMMFWANYGREEIS
ANGTSFLNRIEAMNCERIITKLFRDGVKPEQIGVITPYEGQRAYILQYMQ
MNGSLDKDLYIKVEVASVDAFQGREKDYIILSCVRANEQQAIGFLRDPRR
LNVGLTRAKYGLVILGNPRSLARNTLWNHLLIHFREKGCLVEGTLDNLQL
CTVQLV
Ligand information
Ligand IDALF
InChIInChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
InChIKeyUYOMQIYKOOHAMK-UHFFFAOYSA-J
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al-](F)(F)F
FormulaAl F4
NameTETRAFLUOROALUMINATE ION
ChEMBL
DrugBankDB04444
ZINC
PDB chain2xzl Chain A Residue 1855 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2xzl Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and its Regulation by Upf2.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		P432 G433 K436 Q601 R639 G767 R801
Binding residue
(residue number reindexed from 1)		P338 G339 K342 Q507 R545 G673 R707
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xzl, PDBe:2xzl, PDBj:2xzl
PDBsum2xzl
PubMed21419344
UniProtP30771|RENT1_YEAST ATP-dependent helicase NAM7 (Gene Name=NAM7)

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