Structure of PDB 2byo Chain A Binding Site BS06

Receptor Information

>2byo Chain A (length=183) Species: 83332 (Mycobacterium tuberculosis H37Rv)

SDPALLAEIRQSLDATKGLTSVHVAVRTTGKVDSLLGITSADVDVRANPL
AAKGVCTYNDEQGVPFRVQGDNISVKLFDDWSNLGSISELSTSRVGVTQL
LSGVTNLQAQGTEVIDGISTTKITGTIPASSVKMLDPGAKSARPATVWIA
QDGSHHLVRASIDLGSGSIQLTQSKWNEPVNVD

Ligand information

• Ligand ID: OAA
• InChI: InChI=1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)/p-1
• InChIKey: KHPXUQMNIQBQEV-UHFFFAOYSA-M
• SMILES:
  ACDLabs 10.04: [O-]C(=O)CC(=O)C(=O)O
  OpenEye OEToolkits 1.5.0: C(C(=O)C(=O)O)C(=O)[O-]
  CACTVS 3.341: OC(=O)C(=O)CC([O-])=O
• Formula: C4 H3 O5
• Name: OXALOACETATE ION
• DrugBank: DB02637
• PDB chain: 2byo Chain A Residue 1218

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2byo Lppx is a Lipoprotein Required for the Translocation of Phthiocerol Dimycocerosates to the Surface of Mycobacterium Tuberculosis.
• Resolution: 2.15 Å
• Binding residue (original residue number in PDB): K72 P84 W100
• Binding residue (residue number reindexed from 1): K53 P65 W81
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005319 lipid transporter activity

Biological Process

• GO:0006869 lipid transport
• GO:0071770 DIM/DIP cell wall layer assembly

Cellular Component

• GO:0005576 extracellular region
• GO:0005886 plasma membrane
• GO:0009274 peptidoglycan-based cell wall
• GO:0009986 cell surface

External links

• PDB: RCSB:2byo, PDBe:2byo, PDBj:2byo
• PDBsum: 2byo
• PubMed: 16541102
• UniProt: P9WK65|LPPX_MYCTU Putative phthiocerol dimycocerosate transporter LppX (Gene Name=lppX)