Structure of PDB 1t3t Chain A Binding Site BS06

Receptor Information
>1t3t Chain A (length=1284) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLVPRGSHMMEILRGSPALSAFRINKLLARFQAANLQVHNIYAEYVHFAD
LNAPLNDSEQAQLTRLLQYGPALSSHTPAGKLLLVTPRPGTISPWSSKAT
DIAHNCGLQQVDRLERGVAYYIEASTLTAEQWRQVAAELHDRMMETVFSS
LTDAEKLFIHHQPAPVSSVDLLGEGRQALIDANLRLGLALAEDEIDYLQE
AFTKLGRNPNDIELYMFAQANSEHCRHKIFNADWIIDGKPQPKSLFKMIK
NTFETTPDYVLSAYKDNAAVMEGSAVGRYFADHNTGRYDFHQEPAHILMK
VETHNHPTAISPWPGAATGSGGEIRDEGATGRGAKPKAGLVGFSVSNLRI
PGFEQPWEEDFGKPERIVTALDIMTEGPLGGAAFNNEFGRPALTGYFRTY
EEKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEIVVGAKLIVLGGP
AMNIGFASVQRDNPEMERRCQEVIDRCWQLGDANPILFIHDVGAGGLSNA
MPELVSDGGRGGKFELRDILSDEPGMSPLEIWCNESQERYVLAVAADQLP
LFDELCKRERAPYAVIGDATEEQHLSLHDNHFDNQPIDLPLDVLLGKTPK
MTRDVQTLKAKGDALNRADITIADAVKRVLHLPTVAEKTFLVTIGDRTVT
GMVARDQMVGPWQVPVADCAVTTASLDSYYGEAMSIGERAPVALLDFAAS
ARLAVGEALTNIAATQIGDIKRIKLSANWMAAAGHPGEDAGLYDAVKAVG
EELCPQLGLTIPVGKDSMSMKTRWQEGNEQREMTSPLSLVISAFARVEDV
RHTLTPQLSTEDNALLLIDLGKGHNALGATALAQVYRQLGDKPADVRDVA
QLKGFYDAMQALVAARKLLAWHDRSDGGLLVTLAEMAFAGHCGVQVDIAA
LGDDHLAALFNEELGGVIQVRAEDRDAVEALLAQYGLADCVHYLGQALAG
DRFVITANDQTVFSESRTTLRVWWAETTWQMQRLRDNPQCADQEHEAKAN
DTDPGLNVKLSFDINEDIAAPYIATGARPKVAVLREQGVNSHVEMAAAFH
RAGFDAIDVHMSDLLGGRIGLGNFHALVACGGFSYGDVLGAGEGWAKSIL
FNHRVRDEFETFFHRPQTLALGVCNGCQMMSNLRELIPGSELWPRFVRNH
SDRFEARFSLVEVTQSPSLLLQGMVGSQMPIAVSHGEGRVEVRDDAHLAA
LESKGLVALRYVDNFGKVTETYPANPNGSPNGITAVTTENGRVTIMMPHP
ERVFRTVANSWHPENWGEDSPWMRIFRNARKQLG
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain1t3t Chain A Residue 2012 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1t3t Domain Organization of Salmonella typhimurium Formylglycinamide Ribonucleotide Amidotransferase Revealed by X-ray crystallography
Resolution1.9 Å
Binding residue
(original residue number in PDB)		H1086 R1126 Q1128
Binding residue
(residue number reindexed from 1)		H1075 R1115 Q1117
Annotation score1
Enzymatic activity
Enzyme Commision number 6.3.5.3: phosphoribosylformylglycinamidine synthase.
Gene Ontology
Molecular Function
GO:0004642 phosphoribosylformylglycinamidine synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process
GO:0006541 glutamine metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1t3t, PDBe:1t3t, PDBj:1t3t
PDBsum1t3t
PubMed15301531
UniProtP74881|PUR4_SALTY Phosphoribosylformylglycinamidine synthase (Gene Name=purL)

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