Structure of PDB 1mcx Chain A Binding Site BS06

Receptor Information
>1mcx Chain A (length=304) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TFNPSSDVEALHKAITVKGVDEATIIEILTKRTNAQRQQIKAAYLQEKGK
PLDEALKKALTGHLEEVALALLKTPAQFDADELRAAMKGLGTDEDTLNEI
LASRTNREIREINRVYKEELKRDLAKDITSDTSGDYQKALLSLAKGDRSE
DLAINDDLADTDARALYEAGERRKGTDLNVFITILTTRSYPHLRRVFQKY
SKYSKHDMNKVLDLELKGDIENCLTVVVKCATSKPMFFAEKLHQAMKGIG
TRHKTLIRIMVSRSEIDMNDIKACYQKLYGISLCQAILDETKGDYEKILV
ALCG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1mcx Chain A Residue 352 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1mcx A Calcium-driven Conformational Switch of the N-terminaland Core Domains of Annexin A1
Resolution2.03 Å
Binding residue
(original residue number in PDB)		M286 G288 G290 E330
Binding residue
(residue number reindexed from 1)		M246 G248 G250 E290
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0019834 phospholipase A2 inhibitor activity
GO:0046872 metal ion binding
Biological Process
GO:0002250 adaptive immune response
GO:0002548 monocyte chemotaxis
GO:0002685 regulation of leukocyte migration
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0008360 regulation of cell shape
GO:0030036 actin cytoskeleton organization
GO:0032652 regulation of interleukin-1 production
GO:0032743 positive regulation of interleukin-2 production
GO:0042102 positive regulation of T cell proliferation
GO:0042119 neutrophil activation
GO:0045087 innate immune response
GO:0045627 positive regulation of T-helper 1 cell differentiation
GO:0045629 negative regulation of T-helper 2 cell differentiation
GO:0045920 negative regulation of exocytosis
GO:0046883 regulation of hormone secretion
GO:0050727 regulation of inflammatory response
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071621 granulocyte chemotaxis
GO:0090303 positive regulation of wound healing
Cellular Component
GO:0001891 phagocytic cup
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031514 motile cilium
GO:0031901 early endosome membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1mcx, PDBe:1mcx, PDBj:1mcx
PDBsum1mcx
PubMed12595246
UniProtP19619|ANXA1_PIG Annexin A1 (Gene Name=ANXA1)

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