Structure of PDB 1cvr Chain A Binding Site BS06

Receptor Information
>1cvr Chain A (length=432) Species: 837 (Porphyromonas gingivalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YTPVEEKENGRMIVIVAKKYEGDIKDFVDWKNQRGLRTEVKVAEDIASPV
TANAIQQFVKQEYEKEGNDLTYVLLVGDHKDIPAKITPGIKSDQVYGQIV
GNDHYNEVFIGRFSCESKEDLKTQIDRTIHYERNITTEDKWLGQALCIAS
AEGGPSADNGESDIQHENVIANLLTQYGYTKIIKCYDPGVTPKNIIDAFN
GGISLVNYTGHGSETAWGTSHFGTTHVKQLTNSNQLPFIFDVACVNGDFL
FSMPCFAEALMRAQKDGKPTGTVAIIASTIDQYWAPPMRGQDEMNEILCE
KHPNNIKRTFGGVTMNGMFAMVEKYKKDGENMLDTWTVFGDPSLLVRTLV
PTEMQVTAPANISASAQTFEVACDYNGAIATLSDDGDMVGTAIVKDGKAI
IKLNESIADETNLTLTVVGYNKVTVIKDVKVE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1cvr Chain A Residue 507 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1cvr Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E152 H211
Binding residue
(residue number reindexed from 1)		E152 H211
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) E152 H211 G212 C244
Catalytic site (residue number reindexed from 1) E152 H211 G212 C244
Enzyme Commision number 3.4.22.37: gingipain R.
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1cvr, PDBe:1cvr, PDBj:1cvr
PDBsum1cvr
PubMed10523290
UniProtP95493|CPG2_PORGI Gingipain R2 (Gene Name=rgpB)

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