Structure of PDB 6zvj Chain 1 Binding Site BS06

Receptor Information
>6zvj Chain 1 (length=576) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQSKIAWISET
LCIGCGICIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRPG
EVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQ
NYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQ
LDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRL
KAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVTMPF
SVREGINIFLDGYVPTENLRFRDASYKYPGMKKKMGEFELAIVAGEFTDS
EIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKSTG
SVRQLLHEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVAL
ALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDF
IMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLEITFRRDPNN
YRPRINKLNSIKDVEQKKSGNYFFLD
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6zvj Chain 1 Residue 606 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6zvj A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		S117 Q171 D241
Binding residue
(residue number reindexed from 1)		S114 Q168 D238
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017111 ribonucleoside triphosphate phosphatase activity
GO:0043024 ribosomal small subunit binding
GO:0043273 CTPase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0060698 endoribonuclease inhibitor activity
Biological Process
GO:0000054 ribosomal subunit export from nucleus
GO:0006413 translational initiation
GO:0006415 translational termination
GO:0006417 regulation of translation
GO:0032790 ribosome disassembly
GO:0060702 negative regulation of endoribonuclease activity
GO:0072344 rescue of stalled ribosome
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0016020 membrane
GO:0022626 cytosolic ribosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zvj, PDBe:6zvj, PDBj:6zvj
PDBsum6zvj
PubMed33289941
UniProtP61221|ABCE1_HUMAN ATP-binding cassette sub-family E member 1 (Gene Name=ABCE1)

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